Fernandez-De-Los-Reyes, I.; Gomez-Dorronsoro, M.; Monreal-Santesteban, I.; Fernandez-Fernandez, A.; Fraga, M.; Azcue, P.; Alonso, L.; Fernandez-Marlasca, B.; Suarez, J.; Cordoba-Iturriagagoitia, A.; et al. ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer. Clinical Epigenetics 2023, 15, doi:10.1186/s13148-023-01605-7.
Fernandez-De-Los-Reyes, I.; Gomez-Dorronsoro, M.; Monreal-Santesteban, I.; Fernandez-Fernandez, A.; Fraga, M.; Azcue, P.; Alonso, L.; Fernandez-Marlasca, B.; Suarez, J.; Cordoba-Iturriagagoitia, A.; et al. ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer. Clinical Epigenetics 2023, 15, doi:10.1186/s13148-023-01605-7.
Fernandez-De-Los-Reyes, I.; Gomez-Dorronsoro, M.; Monreal-Santesteban, I.; Fernandez-Fernandez, A.; Fraga, M.; Azcue, P.; Alonso, L.; Fernandez-Marlasca, B.; Suarez, J.; Cordoba-Iturriagagoitia, A.; et al. ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer. Clinical Epigenetics 2023, 15, doi:10.1186/s13148-023-01605-7.
Fernandez-De-Los-Reyes, I.; Gomez-Dorronsoro, M.; Monreal-Santesteban, I.; Fernandez-Fernandez, A.; Fraga, M.; Azcue, P.; Alonso, L.; Fernandez-Marlasca, B.; Suarez, J.; Cordoba-Iturriagagoitia, A.; et al. ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer. Clinical Epigenetics 2023, 15, doi:10.1186/s13148-023-01605-7.
Abstract
Colon cancer (CC) is one of the leading causes of cancer-related death worldwide. Gene hypermethylation is a well-known alteration that contributes to tumour progression in CC. It is essential to analyse new molecular markers that can delineate more aggressive CC cases. The detection of new epigenetic alterations such as hypermethylation and hypomethylation of regulatory gene regions that participate in crucial mechanisms of cancer progression, such as epithelial mesenchymal transition (EMT), could be useful for identifying cases that might benefit from a closer follow-up by clinicians. In the present report we describe, for the first time, the hypermethylation of the ZEB1 gene, which is more frequent in cases without expression of hMLH1. More importantly, this epigenetic alteration is a good prognostic factor related to disease-free and overall survival in all cases and Consensus Molecular Subtypes (CMS2/3) independently of other clinical parameters such as patient age, stage, lymph node involvement, and blood vessel and perineural invasion.
Keywords
methylation; prognosis; colon cancer; biomarkers
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
