Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recent Advances in the Study of Huntingtin Interacting Proteins

SHIHUA Li
* ORCID logo ,
Huichun Tong
ORCID logo ,
Gongke Zhou
,
Li Liu
,
Xing-xing Chen
,
Xiao-Jiang Li
,
Yize Sun
,
Tianqi Yang
ORCID logo
Version 1 : Received: 7 July 2023 / Approved: 10 July 2023 / Online: 10 July 2023 (11:39:26 CEST)

A peer-reviewed article of this Preprint also exists.

Liu, L.; Tong, H.; Sun, Y.; Chen, X.; Yang, T.; Zhou, G.; Li, X.-J.; Li, S. Huntingtin Interacting Proteins and Pathological Implications. Int. J. Mol. Sci. 2023, 24, 13060. Liu, L.; Tong, H.; Sun, Y.; Chen, X.; Yang, T.; Zhou, G.; Li, X.-J.; Li, S. Huntingtin Interacting Proteins and Pathological Implications. Int. J. Mol. Sci. 2023, 24, 13060.

Abstract

Huntington's disease (HD) is caused by an expansion of a CAG repeat in the gene that encodes the huntingtin protein (HTT). The exact function of HTT is still not fully understood, and previous studies have mainly focused on identifying proteins that interact with HTT to gain insights into its function. Numerous HTT-interacting proteins have been discovered, shedding light on the functions and structure of HTT. Most of these proteins interact with the N-terminal region of HTT. Among the various HTT-interacting proteins, huntingtin-associated protein 1 (HAP1) and HTT-interacting protein 1 (HIP1) have been extensively studied. Recent research has uncovered differences in the distribution of HAP1 in monkey and human brains compared to mice. This finding suggests that there may be species-specific variations in the regulation and function of HTT-interacting proteins. Understanding these differences could provide crucial insights into the development of HD. In this review, we will focus on the recent advancements in the study of HTT-interacting proteins, with particular attention to the differential distributions of HTT and HAP1 in larger animal models.

Keywords

Huntingtin; Protein interaction; Huntington’s disease; Polyglutamine

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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