Version 1
: Received: 4 July 2023 / Approved: 7 July 2023 / Online: 7 July 2023 (10:41:49 CEST)
How to cite:
Gavrilova, N.Y.; Normatov, M.G.; Soprun, L.A.; Utekhin, V.J.; Fedotkina, T.V.; Churilov, L.P. Autoantigens of Nervous System and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?. Preprints2023, 2023070489. https://doi.org/10.20944/preprints202307.0489.v1
Gavrilova, N.Y.; Normatov, M.G.; Soprun, L.A.; Utekhin, V.J.; Fedotkina, T.V.; Churilov, L.P. Autoantigens of Nervous System and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?. Preprints 2023, 2023070489. https://doi.org/10.20944/preprints202307.0489.v1
Gavrilova, N.Y.; Normatov, M.G.; Soprun, L.A.; Utekhin, V.J.; Fedotkina, T.V.; Churilov, L.P. Autoantigens of Nervous System and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?. Preprints2023, 2023070489. https://doi.org/10.20944/preprints202307.0489.v1
APA Style
Gavrilova, N.Y., Normatov, M.G., Soprun, L.A., Utekhin, V.J., Fedotkina, T.V., & Churilov, L.P. (2023). Autoantigens of Nervous System and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?. Preprints. https://doi.org/10.20944/preprints202307.0489.v1
Chicago/Turabian Style
Gavrilova, N.Y., Tamara V. Fedotkina and Leonid P. Churilov. 2023 "Autoantigens of Nervous System and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?" Preprints. https://doi.org/10.20944/preprints202307.0489.v1
Abstract
In post-COVID-19 syndrome, clinical presentation of the nerve fiber dysfunction plays an important role. The possibility of autoantigen cross-mimicry of coronavirus infection and the peripheral nervous system need to be investigated. The bioinformatic analysis was applied to search for possible common protein sequences located in the immunological epitopes. Among the autoantigens of the human nervous system, fibroblast growth factor receptor protein 3, myelin protein P0, myelin protein P2, sodium channel protein type 9, alpha protein subunit, plexin-D1 protein and ubiquitin-carboxyl-terminal hydrolase protein of the L1 isoenzyme were selected. The “Alignmentaj” program was created. The UniProt database, Protein Data Bank and AlphaFold databases were used. The analysis of protein sequence similarities of spike glycoproteins in human coronaviruses revealed common pentapeptides of the MERS-CoV-2 virus with the fibroblast growth factor receptor 3 and myelin protein P2. Among seasonal coronaviruses, common peptide sequences were identified in HCoV-HKU-1 virus with sodium channel protein type 9 subunit alpha and Plexin-D1, HCoV-OС43 with Plexin-D1, as well as HCoV-NL63 with Plexin-D1 and Ubiquitin carboxyl-terminal hydrolase isozyme L1. The data obtained make it possible to identify new potential targets for the development of autoimmune reactions that occur against the background of the activity of highly pathogenic and seasonal coronaviruses.
Keywords
molecular mimicry; post-COVID-19 syndrome; SARS-CoV-2; human coronaviruses; autoimmunity; autoantigens of nervous system
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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