Martinez-Castillo, M.; M. Elsayed, A.; López-Berestein, G.; Amero, P.; Rodríguez-Aguayo, C. An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer. Non-Coding RNA2023, 9, 70.
Martinez-Castillo, M.; M. Elsayed, A.; López-Berestein, G.; Amero, P.; Rodríguez-Aguayo, C. An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer. Non-Coding RNA 2023, 9, 70.
Martinez-Castillo, M.; M. Elsayed, A.; López-Berestein, G.; Amero, P.; Rodríguez-Aguayo, C. An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer. Non-Coding RNA2023, 9, 70.
Martinez-Castillo, M.; M. Elsayed, A.; López-Berestein, G.; Amero, P.; Rodríguez-Aguayo, C. An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer. Non-Coding RNA 2023, 9, 70.
Abstract
The noncoding RNAs (ncRNAs) are small transcript sequences that do not encode proteins but participate in the regulation of gene expression at the post-transcriptional level playing important biological roles such as proliferation and differentiation. In the tumor microenvironment, the dysregulated immunological response can participate in the progression and negative phenotype of cancer, the variability of switch cell differentiation and activation of the different immune cell lineages showed differential regulation by the type of cancer. Recent evidence showed that the upregulation of lncRNA can be used as a biomarker and predictive indicator for cancer progression. The use of lncRNA to turn off the tumor immune response and activate the anti-tumoral immune response is day by day a promising reality for the control of cancer. However, is imperatively elucidated the role of each ncRNA identified as well as its respective molecular pathways regulated, including the immune checkpoints, before its application at the clinical level. The correct delivery of lncRNA or mimics to inhibit its expression using the most efficient carriers to the cell or cellular organelle is a science that should continue to be developed.
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