Review
Version 1
Preserved in Portico This version is not peer-reviewed
Compromised Mitotic Fidelity in Human Pluripotent Stem Cells
Version 1
: Received: 28 June 2023 / Approved: 29 June 2023 / Online: 29 June 2023 (11:37:18 CEST)
A peer-reviewed article of this Preprint also exists.
Milagre, I.; Pereira, C.; Oliveira, R.A. Compromised Mitotic Fidelity in Human Pluripotent Stem Cells. Int. J. Mol. Sci. 2023, 24, 11933. Milagre, I.; Pereira, C.; Oliveira, R.A. Compromised Mitotic Fidelity in Human Pluripotent Stem Cells. Int. J. Mol. Sci. 2023, 24, 11933.
Abstract
Human pluripotent stem cells (PSCs), which include both embryonic and induced pluripotent stem cells, are widely used in fundamental and applied biomedical research. They have been instrumental for better understanding development and cell differentiation processes, disease origin and progression, and can aid in the discovery of new drugs. PSCs also hold great potential in regenerative medicine to treat or diminish the effects of certain debilitating diseases, such as degenerative disorders. However, some concerns have recently been raised over their safety for the use in regenerative medicine. One of the major concerns is the fact that PSCs are prone to errors in passing the correct number of chromosomes to daughter cells, resulting in aneuploid cells. Aneuploidy, characterised by an imbalance in chromosome number, elicits the upregulation of different stress pathways that are deleterious to cell homeostasis, impair proper embryo development and can potentiate cancer development. In this review we will summarise known molecular mechanisms recently revealed to impair mitotic fidelity in human PSCs and the consequences of the decreased mitotic fidelity of these cells. We will finish with speculative views on how the physiological characteristics of PSCs can affect the mitotic machinery and how their suboptimal mitotic fidelity may be circumvented.
Keywords
Human Pluripotent Stem Cells; Mitotic Fidelity; Aneuploidy
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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