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Regulation of Pol II Pausing During Daily Gene Transcription in the Mouse Liver
Version 1
: Received: 27 June 2023 / Approved: 27 June 2023 / Online: 27 June 2023 (14:32:42 CEST)
A peer-reviewed article of this Preprint also exists.
Xu, W.; Li, X. Regulation of Pol II Pausing during Daily Gene Transcription in Mouse Liver. Biology 2023, 12, 1107. Xu, W.; Li, X. Regulation of Pol II Pausing during Daily Gene Transcription in Mouse Liver. Biology 2023, 12, 1107.
Abstract
Cell autonomous circadian oscillation is present in central and various peripheral tissues. The intrinsic tissue clock and various extrinsic cues drive gene expression rhythms. Transcription regulation is thought to be the main driving force for gene rhythms. However, how transcription rhythms arise remains to be fully characterized, due to the fact that transcription is regulated at multiple steps. In particular, Pol II recruitment and pause release are two critical regulatory steps that determine the status of Pol II pausing. Recently, we showed that Pol II pausing exhibits genomewide changes during daily transcription in mouse liver. In this article, we review historical as well as recent findings on the regulation of transcription rhythms. We also discuss the possible mechanisms for daily changes in Pol II pausing and the critical involvement of Pol II pausing regulation in generating rhythmic transcription output.
Keywords
circadian rhythms; transcription; pausing; mammalian; mouse
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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