Version 1
: Received: 20 June 2023 / Approved: 27 June 2023 / Online: 27 June 2023 (11:20:58 CEST)
How to cite:
Dyakin, V.V. Enigma of Pyramidal Neurons: Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function. Preprints2023, 2023061885. https://doi.org/10.20944/preprints202306.1885.v1
Dyakin, V.V. Enigma of Pyramidal Neurons: Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function. Preprints 2023, 2023061885. https://doi.org/10.20944/preprints202306.1885.v1
Dyakin, V.V. Enigma of Pyramidal Neurons: Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function. Preprints2023, 2023061885. https://doi.org/10.20944/preprints202306.1885.v1
APA Style
Dyakin, V.V. (2023). Enigma of Pyramidal Neurons: Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function. Preprints. https://doi.org/10.20944/preprints202306.1885.v1
Chicago/Turabian Style
Dyakin, V.V. 2023 "Enigma of Pyramidal Neurons: Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function" Preprints. https://doi.org/10.20944/preprints202306.1885.v1
Abstract
In bilaterians organism, the signaling of pyramidal neurons (PyrNs) is linked to the relative (prevalent) molecular chirality and physiological, perceptual, cognitive, and psychological functions and dysfunctions, providing the coupling of the central nervous system downstream and upstream evolutionary and developmental processes. The most apparent and discriminating morphological specificity of PyrNs is the geometry of the cell body. However, the question "why/how PyrNs soma gains the shape of quasi-tetrahedral symmetry" has never been explicitly articulated. If the basic function of PyrNs is sensory space perception, supporting the orientation, and movement coordination, then the pyramidal shape of soma is the best evolutionary-selected geometry to perform sensory-motor coupling. In biology, the impact of chiral symmetry (handedness) is evident at all levels of biological organization, from the prevalent symmetry of biological molecules to the morphology and function of bilateral organisms. How the tetrahedral symmetry of biomolecules is linked to the morphology and functions of bilateral organisms remains a challenging question. Cell chirality represents an intermediate point connecting two poles of biochirality. In this holistic perspective, examining the PyrNs' morphology-circuitry-function link is crucial to understanding the complex interaction between genetic, epigenetic, and environmental factors in the evolution of the CNS. The predictive power of our hypothesis can be partially expressed by the statement that the most integral and reliable biomarker of the neurodegenerative (including aging) and mental (including all variants of psychiatric illness) disorders would be the detection of the hemispheric asymmetry of D-amino acids (D-AAs) level in pyramidal neurons (PyrNs).
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
