Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and its Therapeutics

Ashok Iyaswamy
* ORCID logo ,
Kejia Lu
,
Xinjie Guan
,
Kan Yuxuan
,
Chengfu Su
ORCID logo ,
Jia Liu
,
Ravindran Jaganathan
ORCID logo ,
Karthick Vasudevan
,
Jeyakumari Paul
,
Min Li
* ORCID logo
Version 1 : Received: 26 June 2023 / Approved: 27 June 2023 / Online: 27 June 2023 (09:27:15 CEST)

A peer-reviewed article of this Preprint also exists.

Iyaswamy, A.; Lu, K.; Guan, X.-J.; Kan, Y.; Su, C.; Liu, J.; Jaganathan, R.; Vasudevan, K.; Paul, J.; Thakur, A.; Li, M. Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics. Biomedicines 2023, 11, 2056. Iyaswamy, A.; Lu, K.; Guan, X.-J.; Kan, Y.; Su, C.; Liu, J.; Jaganathan, R.; Vasudevan, K.; Paul, J.; Thakur, A.; Li, M. Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics. Biomedicines 2023, 11, 2056.

Abstract

Bacterial Extracellular Vesicles (BEVs) generated from the bacteria has high feasibility of intracellular interactions with other cells, can be used as a cargo to deliver any therapeutic substances like monoclonal antibodies, proteins, plasmids, siRNA and small molecules for the treatment of neurodegenerative diseases (NDs). BEVs have a high ability for delivering therapeutic molecules across the blood-brain barrier to treat Alzheimer's Disease (AD) via various mechanisms. In this review, we have sum up in-depth research details of the role and advancement of BEVs in NDs, AD and its Therapeutics. Moreover, details about offensive and defensive functions of BEVs in ND pathogenesis and examine the critical BEV networks in the microbiome-gut-brain axis and their role in neurodegenerative disorders. Additionally determining the roles of BEVs in the neuroimmune system and their interaction with neurodegenerative disorders and exploring the risk factors of BEVs in the autophagy-lysosomal pathway and their possible effects on neurodegenerative disorders are summarised in detail. In conclusion, this review seeks to contribute to a better understanding of the potential function of BEVs in NDs and to identify new therapeutic intervention strategies.

Keywords

Bacterial Extracellular Vesicles; Therapeutics; Neurodegenerative Disease; Alzheimer's Disease; Nanocarriers

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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