Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Malaria Elimination in Africa: Rethinking Strategies for P. vivax and Lessons From Botswana

Isaac K. Quaye
* ,
Larysa Aleksenko
,
Giacomo M. Paganotti
ORCID logo ,
Elias Peloewetse
,
Daniel H. Haiyambo
,
Davies Ntebela
,
Claude Oeuvray
,
Beatrice Greco
Version 1 : Received: 26 June 2023 / Approved: 26 June 2023 / Online: 26 June 2023 (09:55:55 CEST)

A peer-reviewed article of this Preprint also exists.

Quaye, I.K.; Aleksenko, L.; Paganotti, G.M.; Peloewetse, E.; Haiyambo, D.H.; Ntebela, D.; Oeuvray, C.; Greco, B.; the PAVON Consortium. Malaria Elimination in Africa: Rethinking Strategies for Plasmodium vivax and Lessons from Botswana. Trop. Med. Infect. Dis. 2023, 8, 392. Quaye, I.K.; Aleksenko, L.; Paganotti, G.M.; Peloewetse, E.; Haiyambo, D.H.; Ntebela, D.; Oeuvray, C.; Greco, B.; the PAVON Consortium. Malaria Elimination in Africa: Rethinking Strategies for Plasmodium vivax and Lessons from Botswana. Trop. Med. Infect. Dis. 2023, 8, 392.

Abstract

The global malaria community has picked up the theme of malaria elimination in greater than 90 % of the world’s population in the next decade. The recent reports of P. vivax in all sub-Saharan Africa, including Duffy negative individuals, threaten the efforts to achieve elimination. This is not only in view of strategies that are tailored only to P. falciparum elimination, but also due to currently revealed biological characteristics of P. vivax concerning the relapse patterns of hypnozoites and conservation of a large biomass at cryptic sites in the bone marrow and spleen. A typical scenario has been observed in Botswana from the period between 2008 to 2018, which palpably projects how P. vivax could endanger efforts at malaria elimination where the two parasites co-exist. The need for the global malaria community, NMPs, funding agencies and relevant stakeholders to engage in a forum to discuss and recommend clear pathways for sub-Saharan Africa regarding malaria elimination including P. vivax, is warranted.

Keywords

P. vivax; Botswana; Malaria eliminatio; P. vivax biology; malaria and sinusoids

Subject

Biology and Life Sciences, Parasitology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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