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Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Keratinocytes Exposed to Airborne Particulate Matter
Jeong, M.; Ju, Y.; Kwon, H.; Kim, Y.; Hyun, K.-Y.; Choi, G.-E. Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter. Curr. Issues Mol. Biol.2023, 45, 5950-5966.
Jeong, M.; Ju, Y.; Kwon, H.; Kim, Y.; Hyun, K.-Y.; Choi, G.-E. Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter. Curr. Issues Mol. Biol. 2023, 45, 5950-5966.
Jeong, M.; Ju, Y.; Kwon, H.; Kim, Y.; Hyun, K.-Y.; Choi, G.-E. Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter. Curr. Issues Mol. Biol.2023, 45, 5950-5966.
Jeong, M.; Ju, Y.; Kwon, H.; Kim, Y.; Hyun, K.-Y.; Choi, G.-E. Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter. Curr. Issues Mol. Biol. 2023, 45, 5950-5966.
Abstract
Saussurea neoserrata Nakai offers a reliable and efficient source of antioxidants that can help alleviate adverse skin reactions triggered by air pollutants. Air pollutants, such as particulate matter (PM), have the ability to infiltrate the skin and contribute to the higher occurrence of cardiovascular, cerebrovascular, and respiratory ailments. Individuals with compromised skin barriers are particularly susceptible to the impact of PM since it can be absorbed more readily through the skin. This study investigated the impact of protocatechuic acid and syringin, obtained from the n-BuOH extract of S. neoserrata Nakai, on the release of PGE2 and PGD2 induced by PM10. Additionally, it examined the gene expression of enzymes involved in the synthesis of PGE2 and PGD2 in human keratinocytes. The findings of this research highlight the potential of utilizing safe and efficient plant-derived antioxidants in dermatological and cosmetic applications to mitigate the negative skin reactions caused by exposure to air pollution.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
