A Comparative Investigation of Chemical Decontamination Methods for In Situ Cleaning of Dental Implant Surfaces

Badra Hussain; Sadia Khan; Anne Eriksson Agger; Jan Eirik Ellingsen; Ståle Petter Lyngstadaas; Jaime Bueno; Håvard J Haugen

doi:10.20944/preprints202306.1704.v1

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preprints.org > medicine and pharmacology > dentistry and oral surgery > doi: 10.20944/preprints202306.1704.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Comparative Investigation of Chemical Decontamination Methods for In Situ Cleaning of Dental Implant Surfaces

Ståle Petter Lyngstadaas

Jaime Bueno

Håvard J Haugen

Version 1 : Received: 23 June 2023 / Approved: 25 June 2023 / Online: 25 June 2023 (03:23:30 CEST)

A peer-reviewed article of this Preprint also exists.

Hussain, B.; Khan, S.; Agger, A.E.; Ellingsen, J.E.; Lyngstadaas, S.P.; Bueno, J.; Haugen, H.J. A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces. J. Funct. Biomater. 2023, 14, 394. Hussain, B.; Khan, S.; Agger, A.E.; Ellingsen, J.E.; Lyngstadaas, S.P.; Bueno, J.; Haugen, H.J. A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces. J. Funct. Biomater. 2023, 14, 394.

Abstract

Surface chemistry evaluation plays a crucial role in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBone®Clean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in- vitro and human testing protocols. X-ray Photoelectron Spectroscopy (XPS) was utilized for surface analysis. All the tested gels had some effect on the surface cleanness except for PrefGel®. Among the tested chemical decontamination candidates, NuBone®Clean demonstrated effectiveness in providing a cleaner titanium surface. Furthermore, none of the tested chemical agents exhibited any cytotoxic effects, and the safety assessment showed no adverse events. The results of this study highlight the significance of conducting comprehensive evaluations, encompassing safety and efficacy, before introducing new chemical agents for dental treatments. The findings suggest that NuBone®Clean shows potential as a chemical decontamination solution for implant surfaces. However, further investigation through randomized clinical trials is necessary. By adhering to rigorous testing protocols, the development of safe and efficient chemical decontamination strategies can be advanced, benefiting patients and promoting progress in the field of implant dentistry.

Keywords

dental implant; acquired pellicle; peri-implant disease; chemical decontamination

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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