PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study
Version 1
: Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (12:38:37 CEST)
How to cite:
Jarosz, K.; Kojder, K.; Andrzejewska, A.; Solek-Pastuszka, J.; Jurczak, A. Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study. Preprints2023, 2023061683. https://doi.org/10.20944/preprints202306.1683.v1
Jarosz, K.; Kojder, K.; Andrzejewska, A.; Solek-Pastuszka, J.; Jurczak, A. Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study. Preprints 2023, 2023061683. https://doi.org/10.20944/preprints202306.1683.v1
Jarosz, K.; Kojder, K.; Andrzejewska, A.; Solek-Pastuszka, J.; Jurczak, A. Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study. Preprints2023, 2023061683. https://doi.org/10.20944/preprints202306.1683.v1
APA Style
Jarosz, K., Kojder, K., Andrzejewska, A., Solek-Pastuszka, J., & Jurczak, A. (2023). Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study. Preprints. https://doi.org/10.20944/preprints202306.1683.v1
Chicago/Turabian Style
Jarosz, K., Joanna Solek-Pastuszka and Anna Jurczak. 2023 "Effects of Cerebrolysin Administration With Association With Additional Amantadine Treatment and Neuromonitoring on the Outcome in Patients With TBI Diagnosis - Results of an Observational Cohort Study" Preprints. https://doi.org/10.20944/preprints202306.1683.v1
Abstract
TBI is one of the most common causes of death and long term damage to health worldwide. The approved guidelines for patients with TBI include standards of treatment. However, there is lack of guidelines for monitoring or neuroprotective treatment. Cerebrolysin is a drug with a proven beneficial effect on treatment outcome in patients with TBI. There are also reports of the beneficial effect of Amantadine. Studies on the use of additional neuromonitoring are also published with increasing frequency. We decided to investigate how the result of treatment changed with the administration of Cerebrolysin and Amantadine and with additional neuromonitoring. In an observational study, we collected data on 56 patients. After the statistical analysis, it could be shown, that Cerebrolysin monotherapy increases Glasgow Outcome Scale (GOS) among our patients and it was found to interact significantly with Amantadine and neuromonitoring approach in the group of severe TBI. In conclusion, it is worth considering a multimodal approach to the treatment and monitoring of patients with TBI. However, more randomized studies are needed to confirm the method of monitoring or conducting neuroprotective therapy in patients with TBI.
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
