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Perspectives of Proteomics in Respiratory Allergic Diseases
Version 1
: Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (09:46:31 CEST)
A peer-reviewed article of this Preprint also exists.
Galván-Morales, M.Á. Perspectives of Proteomics in Respiratory Allergic Diseases. Int. J. Mol. Sci. 2023, 24, 12924. Galván-Morales, M.Á. Perspectives of Proteomics in Respiratory Allergic Diseases. Int. J. Mol. Sci. 2023, 24, 12924.
Abstract
Proteomics in respiratory allergic diseases has such a battery of techniques and programs that one would almost think that there is nothing impossible to find, invent or mold. All these resources that we document here, are involved in solving problems in allergic diseases, both diagnostic, prognostic, treatment and immunotherapy development. The main perspectives, according to this version, are in three strands and / or lockout immunological system: 1) In blocking the diapedesis of cells involved, 2) modifications and blocking of paratopes and epitopes being understood by modifications to antibodies, antagonism or blocking them and 3) blocking FcεR1 receptors to prevent specific IgEs from sticking to mast cells and basophils. These tools and targets in the allergic landscape are, in our view, the prospects in the field.
Keywords
Proteomics; ELISA; mass spectrometry; Liquid chromatography; Luminex; Uniprot; Rosseta comment; Mascot; allergy respiratory disease; inflammation type 2; diapedesis; epitopo
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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