Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Phytochemical Screening and Biological Activities of Opilia amentacea Roxb. (Opiliaceae)

Ollo Youl
* ORCID logo ,
Belinda Ramata Hafouo MonéBassavé
,
Sibidou Yougbaré
,
Boubacar Yaro
,
Tata Kadiatou Traoré
,
Raïnatou Boly
,
Josias B. Gérard Yaméogo
,
Moumouni Koala
ORCID logo ,
Noufou Ouedraogo
,
Elie Kabré
,
Halidou Tinto
,
Maminata TraoréCoulibaly
ORCID logo ,
Adama Hilou
Version 1 : Received: 20 June 2023 / Approved: 21 June 2023 / Online: 21 June 2023 (08:24:19 CEST)

A peer-reviewed article of this Preprint also exists.

Youl, O.; Moné-Bassavé, B.R.H.; Yougbaré, S.; Yaro, B.; Traoré, T.K.; Boly, R.; Yaméogo, J.B.G.; Koala, M.; Ouedraogo, N.; Kabré, E.; Tinto, H.; Traoré-Coulibaly, M.; Hilou, A. Phytochemical Screening, Polyphenol and Flavonoid Contents, and Antioxidant and Antimicrobial Activities of Opilia amentacea Roxb. (Opiliaceae) Extracts. Appl. Biosci. 2023, 2, 493-512. Youl, O.; Moné-Bassavé, B.R.H.; Yougbaré, S.; Yaro, B.; Traoré, T.K.; Boly, R.; Yaméogo, J.B.G.; Koala, M.; Ouedraogo, N.; Kabré, E.; Tinto, H.; Traoré-Coulibaly, M.; Hilou, A. Phytochemical Screening, Polyphenol and Flavonoid Contents, and Antioxidant and Antimicrobial Activities of Opilia amentacea Roxb. (Opiliaceae) Extracts. Appl. Biosci. 2023, 2, 493-512.

Abstract

Dermatoses are essentially due to infectious or free radical aggression, immunoallergic disor-ders, or can be secondary to general diseases. To investigate new antimicrobial sources against dermatoses, Opilia amentacea crude ethanol extracts and fractions were subjected to phytochemical screening and tested for antioxidant and antimicrobial activities on Gram-positive cocci, Gram negative bacilli and fungi. Phytochemical screening revealed secondary metabolites such as sterols, triterpenes, flavonoids and tannins. Leaves and stem bark of Opilia amentacea exhibited the highest total phenolic contain (65,92 ± 0,93 and 65,71 ± 0,57 mg GAE/g DW respectivily) and flavonoids (38,8 ± 1,05 and 26,81 ± 0,19mg QE/g DW respectively). Dichloromethane fractions of leaves (FDFe) and stem bark (FDET) exhibited the best antioxidant activity with FRAP values of 741,15 and 662,84 mMol AAE/g and IC50 values of ABTS of 88,40 and 36,85 µg/mL respectively. These fractions were also the most active on Gram positive bacilli while Hexane leaves (FHFe) and hexane root bark (FHER) fractions exhibited the best antifungal activity against Candida tropicalis at MIC values of 0.23 mg/mL and 0.43 mg/mL respectively. Gram-negative bacteria were particularly resistant. This study constitutes a solid scientific basis that could justify the traditional uses of Opilia amen-tacea as an antidermatosis plant.

Keywords

Opilia amentacea; phytochemical screening; antioxidant activity; antimicrobial activity; Minimal inhibitory concentration; Minimal bactericidal concentration

Subject

Biology and Life Sciences, Plant Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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