The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article.

Mohammed A. Azab

doi:10.20944/preprints202306.1420.v1

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202306.1420.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article.

Mohammed A. Azab

Version 1 : Received: 19 June 2023 / Approved: 20 June 2023 / Online: 21 June 2023 (03:13:00 CEST)

A peer-reviewed article of this Preprint also exists.

Azab, M.A. The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article. J. Mol. Pathol. 2023, 4, 196-212. Azab, M.A. The Potential Role of Histone Modifications in Glioblastoma Therapy: Review Article. J. Mol. Pathol. 2023, 4, 196-212.

Abstract

Glioblastoma is considered the most aggressive primary brain tumor. Recurrence after treatment is a significant problem with a failed response to optimal therapies. The recurrence of GBM is linked to different cellular pathways and molecular pathways. Not only genetics are involved in gliomagenesis, but also epigenetics. Epigenetic mechanisms are highly involved in the pathogenesis of GBM. Histone modulation through acetylation, phosphorylation, ubiquitination, and methylation can regulate gene expression and may play a role in the pathogenesis of GBM. Preclinical and clinical studies currently target epigenetic enzymes in gliomas, including a new generation of histone deacetylase (HDAC) inhibitors. Herein, I tried to highlight the current research in glioma epigenetics, focusing on the culprit of histone modifications and the use of HDAC target therapies as a possible treatment line for glioblastoma.

Keywords

glioma; histone; HDAC; therapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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