Version 1
: Received: 13 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (08:51:35 CEST)
How to cite:
Acharya, M.; Singh, A.; Nidhi, V.; Tiwari, A.; Gandhi, A.; Chaudhari, I. Outcomes of Keratoplasty in a Cohort of Pythium insidiosum Keratitis Cases at a Tertiary Eye Care Center in India. Preprints2023, 2023060900. https://doi.org/10.20944/preprints202306.0900.v1
Acharya, M.; Singh, A.; Nidhi, V.; Tiwari, A.; Gandhi, A.; Chaudhari, I. Outcomes of Keratoplasty in a Cohort of Pythium insidiosum Keratitis Cases at a Tertiary Eye Care Center in India. Preprints 2023, 2023060900. https://doi.org/10.20944/preprints202306.0900.v1
Acharya, M.; Singh, A.; Nidhi, V.; Tiwari, A.; Gandhi, A.; Chaudhari, I. Outcomes of Keratoplasty in a Cohort of Pythium insidiosum Keratitis Cases at a Tertiary Eye Care Center in India. Preprints2023, 2023060900. https://doi.org/10.20944/preprints202306.0900.v1
APA Style
Acharya, M., Singh, A., Nidhi, V., Tiwari, A., Gandhi, A., & Chaudhari, I. (2023). Outcomes of Keratoplasty in a Cohort of <em>Pythium insidiosum</em> Keratitis Cases at a Tertiary Eye Care Center in India. Preprints. https://doi.org/10.20944/preprints202306.0900.v1
Chicago/Turabian Style
Acharya, M., Arpan Gandhi and Isha Chaudhari. 2023 "Outcomes of Keratoplasty in a Cohort of <em>Pythium insidiosum</em> Keratitis Cases at a Tertiary Eye Care Center in India" Preprints. https://doi.org/10.20944/preprints202306.0900.v1
Abstract
Pythium insidiosum(PI) can cause sight threatening keratitis which is managed commonly by performing penetrating keratoplasty. This article is a retrospective review to assess outcomes of keratoplasty performed in patients diagnosed with PI keratitis. (2) Methods: Pre-operative, intra operative and post-operative data of patients diagnosed with PI keratitis and who underwent keratoplasty for their condition from January 2020 to December 2021 were col-lected from the central patient database of a tertiary eye care hospital in India. The data were an-alyzed for anatomic success, elimination of infection, graft survival, incidence of repeat kerato-plasty, final visual acuity and varied complications. (3) Results: In total, 16 eyes underwent pene-trating keratoplasty for PI keratitis during the study period. Mean time to keratoplasty from on-set of symptoms was 31.3 days and mean graft size was 10.4 mm. Nine out of the 16 cases had recurrence of infection following surgery, six of which required a repeat keratoplasty for elimina-tion of infection. Out of these 6 patients, one patient underwent 2 repeat keratoplasties. Mean graft size for repeat keratoplasty performed in recurrent cases was 11.7 mm. Globe was successfully salvaged in 14 out of 16 patients (87.5 %). Endo-exudates, graft infiltration, graft dehiscence, secondary glaucoma and retinal detachment were the various complications noted after kerato-plasty. (4) Conclusion: Keratoplasty remains the choice of treatment in PI keratitis, however re-currence of disease and graft failure are common. Large sized grafts, meticulous per-operative removal of infection, adjuvant cryotherapy, and intraoperative and post-operative use of antibi-otics can help in improving outcome of keratoplasty in these patients.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
