Version 1
: Received: 9 June 2023 / Approved: 9 June 2023 / Online: 9 June 2023 (13:09:26 CEST)
How to cite:
Nsele, N.W.; Thembane, N. Penicillin G and Sutherlandia Frutescens [syn. Lessertia frutescens] (Fabaceae): A Potent Combo Against Enterococcus Faecalis. Preprints2023, 2023060723. https://doi.org/10.20944/preprints202306.0723.v1
Nsele, N.W.; Thembane, N. Penicillin G and Sutherlandia Frutescens [syn. Lessertia frutescens] (Fabaceae): A Potent Combo Against Enterococcus Faecalis. Preprints 2023, 2023060723. https://doi.org/10.20944/preprints202306.0723.v1
Nsele, N.W.; Thembane, N. Penicillin G and Sutherlandia Frutescens [syn. Lessertia frutescens] (Fabaceae): A Potent Combo Against Enterococcus Faecalis. Preprints2023, 2023060723. https://doi.org/10.20944/preprints202306.0723.v1
APA Style
Nsele, N.W., & Thembane, N. (2023). Penicillin G and Sutherlandia Frutescens [syn. Lessertia frutescens] (Fabaceae): A Potent Combo Against Enterococcus Faecalis. Preprints. https://doi.org/10.20944/preprints202306.0723.v1
Chicago/Turabian Style
Nsele, N.W. and Nokukhanya Thembane. 2023 "Penicillin G and Sutherlandia Frutescens [syn. Lessertia frutescens] (Fabaceae): A Potent Combo Against Enterococcus Faecalis" Preprints. https://doi.org/10.20944/preprints202306.0723.v1
Abstract
(1) Background: The emergence of antibiotic-resistant bacteria is a growing concern in the field of
medicine. This has led to the need for alternative treatments for bacterial infections. (2) Methods:
The present study aimed to investigate the synergistic effect of a water-based extract of S. fru-tescens and penicillin G on the growth of E. faecalis. (3) Results: The study found that the combina-tion of the plant extract and penicillin G had a synergistic effect on the inhibition of bacterial growth, with a significantly larger inhibition zone observed compared to penicillin G alone. The MIC and MBC tests also demonstrated that the combination of the plant extract and penicillin G was more effective against E. faecalis than penicillin G alone, with a dilution of 1 in 4 yielding 100% inhibition of growth. (4) Conclusion: Although the specific mechanism of action was not dis-cussed in the study, the results suggest that the combination of the plant extract and penicillin G may offer a promising alternative treatment for antibiotic-resistant infections. Further research is needed to determine the active compounds in the plant extract and to investigate the synergistic effect of the combination on other strains of bacteria.
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
