Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study

Radu Dumitru
* ORCID logo ,
Mugur Cristian Grasu
* ORCID logo ,
Gabriel Iuhas
,
Miruna Elena Ispas
,
Mihai Gheorghe Toma
,
Ioana Gabriela Lupescu
ORCID logo
Version 1 : Received: 8 June 2023 / Approved: 9 June 2023 / Online: 9 June 2023 (04:39:56 CEST)

How to cite: Dumitru, R.; Grasu, M.C.; Iuhas, G.; Ispas, M.E.; Toma, M.G.; Lupescu, I.G. Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study. Preprints 2023, 2023060668. https://doi.org/10.20944/preprints202306.0668.v1 Dumitru, R.; Grasu, M.C.; Iuhas, G.; Ispas, M.E.; Toma, M.G.; Lupescu, I.G. Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study. Preprints 2023, 2023060668. https://doi.org/10.20944/preprints202306.0668.v1

Abstract

(1) Background: Evaluating if necrosis volumetric assessment of pre-/post-RFA in HCC can be an accurate predictor of LTP (local tumor progression) and survival.; (2) Methods: Retrospective, descriptive and analytical study conducted between 01.01.2018 - 30.09.2021 in the Radiology and Medical Imaging Department of Fundeni Clinical Institute. 35 patients, each with one LI-RADS 4 or 5 treated lesion were eligible to be included. Volumetry was performed using OsiriX MD. Initial lesion volume, ideal necrosis volume (0,5-1 cm safety margin) and actual necrosis volume at 1 and 6 months post-procedure were performed; (3) Results: Results and discussions: Actual necrosis volume is influenced by several factors: lesion position, proximity to great vessels or other critical structures. The overall recurrence-free survival rate was similar to data in other studies (77% in the first year post-RFA). This study showed that having the actual necrosis volume at 1 month smaller than ideal necrosis volume is a good predictor for local tumor progression (p < 0,05); (4) Conclusions: Volumetric assessment of necrosis is easily attainable and can help improve prediction of local tumour progression.

Keywords

radiofrequency ablation; hepatocarcinoma; volumetry; local tumour progression.

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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