Bao, Y.; Gan, C.; Chen, Z.; Qi, Z.; Meng, Z.; Yue, F. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sci.2023, 13, 1153.
Bao, Y.; Gan, C.; Chen, Z.; Qi, Z.; Meng, Z.; Yue, F. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sci. 2023, 13, 1153.
Bao, Y.; Gan, C.; Chen, Z.; Qi, Z.; Meng, Z.; Yue, F. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sci.2023, 13, 1153.
Bao, Y.; Gan, C.; Chen, Z.; Qi, Z.; Meng, Z.; Yue, F. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sci. 2023, 13, 1153.
Abstract
Abstract
Background: Parkinson's disease (PD) is a neurodegenerative disorder featured with motor and non-motor deficits. Using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine neuron degeneration has been widely used to produce reliable animal models of the PD. However, most of previous preclinical studies focused on the motor dysfunctions, few non-motor symptoms were evaluated. So far there is a lack of comprehensive investigation of the non-motor symptoms in animal models.
Objectives: In this study, we aim to use a battery of behavioral methods to evaluate the non-motor symptoms in MPTP-induced non-human primate PD models.
Methods: Cognitive functions, sleep and psychiatric behaviors were evaluated in MPTP-treated cynomolgus monkeys. The tests consisted of delayed matching-to-sample (DMTS), physical activity monitor (PAM), apathy feeding task (AFT), human intruder test (HIT), novel fruit test (NFT) and predator confrontation test (PCT). In addition, we tested whether the dopamine receptor agonist pramipexole (PPX) will improve these non-motor symptoms.
Results: The present results show that the MPTP-treated monkeys exhibited cognitive deficits, abnormal sleep, and anxiety-like behaviors as compared to the control monkeys. These symptoms were relieved partially by PPX.
Conclusions: These results suggest that MPTP-induced PD monkeys displayed non-motor symptoms that were similar to those found in PD patients. PPX treatment showed moderate therapeutic effects on these non-motor symptoms. This battery of behavioral tests may provide a valuable model for future preclinical research.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
