Anti-inflammatory and Antioxidant Potential of Pteropodine in Rodents

Paniagua-Pérez, R.; Sánchez-Chapul, L.; Madrigal-Bujaidar, E.; Álvarez-González, I.; Madrigal-Santillán, E.; Cruz-Hernández, L.; Martínez-Canseco, C.; Reyes-Legorreta, C.; Ruiz-Rosano, L.; Hernández-Flores, C.; Valdez-Mijares, R.; Quintana-Armenta, A. Anti-Inflammatory Potential of Pteropodine in Rodents. Metabolites 2023, 13, 907. Paniagua-Pérez, R.; Sánchez-Chapul, L.; Madrigal-Bujaidar, E.; Álvarez-González, I.; Madrigal-Santillán, E.; Cruz-Hernández, L.; Martínez-Canseco, C.; Reyes-Legorreta, C.; Ruiz-Rosano, L.; Hernández-Flores, C.; Valdez-Mijares, R.; Quintana-Armenta, A. Anti-Inflammatory Potential of Pteropodine in Rodents. Metabolites 2023, 13, 907.

Abstract

Background: Pteropodine (PT) is a component of some plants with potentially useful pharmaco-logical activities for humans. This compound has biomedical properties related to the modulation of the immune system, nervous system, and inflammatory processes. This study addresses the an-ti-inflammatory and antioxidant capacity of pteropodin in a murine model of arthritis and induced edema of the mouse ear. Methods: To evaluate the anti-inflammatory activity, we used the reversed passive Arthus reaction (RPAR), which includes the rat paw edema test, the rat pleurisy test, and a mouse ear edema model. The antioxidant effect was evaluated by determining the myeloperoxidase enzyme activity. Results: PT showed an anti-inflammatory effect in the different specific and non-specific tests. We found a 52 to 74% of inhibitory effect of PT in the rat paw edema test, 52% of reduction of the pleural exudate volume, and low neutrophil count (28%), when compared to the control group. We also found a 81% of inflammatory inhibition of the ear edema, and a significant myeloperoxidase enzyme inhibition by the three doses of PT. Conclusions: PT exerted a potent an-ti-inflammatory effect in the acute inflammation model in rodents.

Keywords

anti-inflammatory assays; murine model; rodent-induced edema

Subject

Biology and Life Sciences, Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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