Patamia, V.; Zagni, C.; Fiorenza, R.; Fuochi, V.; Dattilo, S.; Riccobene, P.M.; Furneri, P.M.; Floresta, G.; Rescifina, A. Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity. Nanomaterials2023, 13, 2036.
Patamia, V.; Zagni, C.; Fiorenza, R.; Fuochi, V.; Dattilo, S.; Riccobene, P.M.; Furneri, P.M.; Floresta, G.; Rescifina, A. Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity. Nanomaterials 2023, 13, 2036.
Patamia, V.; Zagni, C.; Fiorenza, R.; Fuochi, V.; Dattilo, S.; Riccobene, P.M.; Furneri, P.M.; Floresta, G.; Rescifina, A. Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity. Nanomaterials2023, 13, 2036.
Patamia, V.; Zagni, C.; Fiorenza, R.; Fuochi, V.; Dattilo, S.; Riccobene, P.M.; Furneri, P.M.; Floresta, G.; Rescifina, A. Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity. Nanomaterials 2023, 13, 2036.
Abstract
Nowadays, there is evidence that bacteria can contribute to cancer formation and interfere with therapy by mediating its carcinogenesis and related infection. Moreover, it is acknowledged that microbial infections and antibiotic resistance represent severe economic and health risks to society. These facts have led to the developing of several new techniques for impeding crucial biological processes in microbial cells. One of these techniques centers on using metal-chelating agents, which can disrupt the microorganism's vital metal metabolism by obstructing metal uptake and bioavailability for critical reactions. Additionally, nanotechnology has made a wide range of nanomaterials available for possible uses in the antibacterial industry. This complex field is shaped by antimicrobial nanoparticles, also investigated as therapeutic and drug-delivery tools. Halloysite nanotubes (HNTs) are naturally occurring tubular clay nanomaterials consisting of aluminosilicate kaolin sheets rolled up several times. The aluminon and siloxane groups on the surface of HNTs facilitate the formation of hydrogen bonds with biomaterials on their surface. These properties make HNTs crucial in a wide range of applications, such as in environmental sciences, wastewater treatment, dye removal, nanoelectronics and nanocomposite fabrication, catalytic studies, coatings for glass or anti-corrosive coatings, cosmetics, flame retardants, stimulus-response, and in forensic sciences. This work aimed to produce an antibacterial material by combining the properties of halloysite nanotubes with the ability of kojic acid to chelate iron. Starting from kojic acid, a simple nucleophilic substitution involving the hydroxyl groups on the surface of the nanotubes was performed. The obtained material was characterized by IR and SEM, and its ability to chelate iron was evaluated. Finally, the capacity to load drugs such as resveratrol and curcumin was also evaluated by UV analysis. In this way, a new bio-based material that can be used as a drug carrier and antimicrobial was produced.
Keywords
resveratrol; curcumin; halloysite nanotubes; kojic acid; iron chelation, antibacterial.
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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