Version 1
: Received: 7 June 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (05:46:20 CEST)
How to cite:
Yahya, N.B.; Ramadhan, A.A. The Clinical and Pathological Characteristics of Neonatal Cholestasis; A Case of Hevi Pediatrics Teaching Hospital in Duhok Province, Iraq. Preprints2023, 2023060494. https://doi.org/10.20944/preprints202306.0494.v1
Yahya, N.B.; Ramadhan, A.A. The Clinical and Pathological Characteristics of Neonatal Cholestasis; A Case of Hevi Pediatrics Teaching Hospital in Duhok Province, Iraq. Preprints 2023, 2023060494. https://doi.org/10.20944/preprints202306.0494.v1
Yahya, N.B.; Ramadhan, A.A. The Clinical and Pathological Characteristics of Neonatal Cholestasis; A Case of Hevi Pediatrics Teaching Hospital in Duhok Province, Iraq. Preprints2023, 2023060494. https://doi.org/10.20944/preprints202306.0494.v1
APA Style
Yahya, N.B., & Ramadhan, A.A. (2023). The Clinical and Pathological Characteristics of Neonatal Cholestasis; A Case of Hevi Pediatrics Teaching Hospital in Duhok Province, Iraq. Preprints. https://doi.org/10.20944/preprints202306.0494.v1
Chicago/Turabian Style
Yahya, N.B. and Ali A Ramadhan. 2023 "The Clinical and Pathological Characteristics of Neonatal Cholestasis; A Case of Hevi Pediatrics Teaching Hospital in Duhok Province, Iraq" Preprints. https://doi.org/10.20944/preprints202306.0494.v1
Abstract
Background:
Neonatal cholestasis (NC) initiates in the first trimester of a newborn, comprising extra and intrahepatic medical conditions, with a high risk of fatality warranting early diagnosis and treatment to prevent morbimortality. The differential diagnosis of NC is a challenge demanding an accurate diagnosis for disease detection. The current study evaluates NC's clinical symptoms and differential diagnosis using ultrasound, liver biopsy, histopathology, and biochemistry.
Methods:
Infant registry data from Hevi Pediatric Teaching Hospital (January 2016 - January 2022) were obtained and screened for subject selection. The inclusion criteria include infants with direct hyperbilirubinemia within an onset of 1 to 90 days of birth. As indicated, the recruited subjects underwent liver ultrasound, blood biochemistry, and liver biopsy.
Results:
Seventy-two children presented with the criteria for inclusion in the study. The study found that ultrasound helped diagnose 43.1% of subjects for BA compared to 34.7% through histopathology. The histopathology confirmed 13 children (18.1%) having neonatal hepatitis. Test sensitivity of the ultrasound method for BA and NH was 60% (40.74, 76.6) and 38.46% (17.71, 64.48), respectively.
Conclusion:
The study found both ultrasound and liver biopsy to be critical diagnostic methods to differentiate the etiology of NC. Ultrasound has a higher specificity and sensitivity for diagnosing BA than NH. Histopathology and blood biochemistry should be considered, too, for effective diagnosis. In the future, larger sample and multicenter studies should be conducted to develop practically implementable strategies.
Keywords
Neonatal Cholestasis; Liver biopsy; Biliary atresia; triangular cord sing
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
