Version 1
: Received: 5 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (16:08:18 CEST)
How to cite:
Mohlala, R.L.; Rashamuse, T.J.; Coyanis, E.M. Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications. Preprints2023, 2023060345. https://doi.org/10.20944/preprints202306.0345.v1
Mohlala, R.L.; Rashamuse, T.J.; Coyanis, E.M. Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications. Preprints 2023, 2023060345. https://doi.org/10.20944/preprints202306.0345.v1
Mohlala, R.L.; Rashamuse, T.J.; Coyanis, E.M. Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications. Preprints2023, 2023060345. https://doi.org/10.20944/preprints202306.0345.v1
APA Style
Mohlala, R.L., Rashamuse, T.J., & Coyanis, E.M. (2023). Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications. Preprints. https://doi.org/10.20944/preprints202306.0345.v1
Chicago/Turabian Style
Mohlala, R.L., Thompho Jason Rashamuse and Elena Mabel Coyanis. 2023 "Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications" Preprints. https://doi.org/10.20944/preprints202306.0345.v1
Abstract
Multicomponent reactions (MCRs) have been used for more than a century; since their discovery in 1850 by Strecker. To date, MCRs route is regarded as a beneficial strategy due to its capacity to quickly produce molecular diversity and structural complexity of interest for a variety of applications. Despite having famous MRCs such as the Ugi, Passerini, Biginelli, and Hantzsch, this re-view portrays the importance of MCRs in the synthesis of desired products towards applications such as medicinal purposes, sustainable chemistry, and polymerisation. MCRs provide ad-vantages such as reducing the number of sequential multiple reactions to one step, atom economy, recyclable catalysts, mild conditions, preventing waste and reduce solvent use.
Keywords
Multicomponent reactions; medicinal chemistry; green chemistry; polymerisation; synthesis
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.