Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications

Version 1 : Received: 5 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (16:08:18 CEST)

How to cite: Mohlala, R.L.; Rashamuse, T.J.; Coyanis, E.M. Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications. Preprints 2023, 2023060345. https://doi.org/10.20944/preprints202306.0345.v1 Mohlala, R.L.; Rashamuse, T.J.; Coyanis, E.M. Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications. Preprints 2023, 2023060345. https://doi.org/10.20944/preprints202306.0345.v1

Abstract

Multicomponent reactions (MCRs) have been used for more than a century; since their discovery in 1850 by Strecker. To date, MCRs route is regarded as a beneficial strategy due to its capacity to quickly produce molecular diversity and structural complexity of interest for a variety of applications. Despite having famous MRCs such as the Ugi, Passerini, Biginelli, and Hantzsch, this re-view portrays the importance of MCRs in the synthesis of desired products towards applications such as medicinal purposes, sustainable chemistry, and polymerisation. MCRs provide ad-vantages such as reducing the number of sequential multiple reactions to one step, atom economy, recyclable catalysts, mild conditions, preventing waste and reduce solvent use.

Keywords

Multicomponent reactions; medicinal chemistry; green chemistry; polymerisation; synthesis

Subject

Chemistry and Materials Science, Organic Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.