Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preparation, Characterization, and In Vitro Evaluation of the Biological Activity of Several Metal-Based Complexes with Two Widely Used Fluoroquinolones Antibiotics: Lomefloxacin and Pefloxacin Drugs

Abdulrahman A. Almehizia
ORCID logo ,
Mohamed A. Al-Omar
ORCID logo ,
Ahmed M. Naglah
* ,
Mashooq A. Bhat
ORCID logo ,
Razan Eskandrani
,
Fatimah A. Alotaibi
,
Moamen S. Refat
,
Abdel Majid A. Adam
Version 1 : Received: 3 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (10:22:12 CEST)

How to cite: Almehizia, A.A.; Al-Omar, M.A.; Naglah, A.M.; Bhat, M.A.; Eskandrani, R.; Alotaibi, F.A.; Refat, M.S.; Adam, A.M.A. Preparation, Characterization, and In Vitro Evaluation of the Biological Activity of Several Metal-Based Complexes with Two Widely Used Fluoroquinolones Antibiotics: Lomefloxacin and Pefloxacin Drugs. Preprints 2023, 2023060305. https://doi.org/10.20944/preprints202306.0305.v1 Almehizia, A.A.; Al-Omar, M.A.; Naglah, A.M.; Bhat, M.A.; Eskandrani, R.; Alotaibi, F.A.; Refat, M.S.; Adam, A.M.A. Preparation, Characterization, and In Vitro Evaluation of the Biological Activity of Several Metal-Based Complexes with Two Widely Used Fluoroquinolones Antibiotics: Lomefloxacin and Pefloxacin Drugs. Preprints 2023, 2023060305. https://doi.org/10.20944/preprints202306.0305.v1

Abstract

Lomefloxacin (F1) and pefloxacin (F2) have a broad spectrum of antimicrobial activities against Gram-positive and Gram-negative bacteria. In this study, we investigated the complexation mode, morphological and biological properties of four metal-based complexes of F1 and F2 molecules with Mg(II), Ca(II), Zn(II), and Fe(III) metal ions. These complexes were prepared at ~60–70°C in a neutral medium using a 5% NH3 solution at pH ~7-8 with a 1:1 ratio. Multiple physicochemical methods were employed to characterize the binding mode between F1 and F2 with the metal ions under investigation. The results of these methods suggested that the gross formula of the complexes obtained with the metal ions were [MgF1(H2O)Cl]2H2O, [CaF1(H2O)Cl]3H2O, [ZnF1(H2O)Cl], [FeF1(H2O)2Cl2]Cl2H2O, [MgF2(H2O)Cl]2H2O, [CaF2(H2O)Cl]3H2O, [ZnF2(H2O)Cl], and [FeF2(H2O)2Cl2]Cl2H2O. The microscopic characterizations indicated that the Ca(II)-F1 complex had an interesting surface topography. Its particles had a homogenous, short, rod-like shaped structure that clustered together to form a tree shape. Using the Kirby-Bauer disc diffusion protocol, the synthesized metal-based complexes were screened in vitro against different Gram-positive and Gram-negative bacterial and fungal species. The antimicrobial profile of the Fe(III)-F1 complex indicated that it had remarkable inhibitory activity against all the tested bacterial and fungal species with potency equal to that of the standard drugs (streptomycin and ketoconazole).

Keywords

Fluoroquinolones; Lomefloxacin; Pefloxacin Metal-based complex; Spectroscopies; Biological activities

Subject

Chemistry and Materials Science, Applied Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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