Kumar, R.; Kim, J.; Deek, M.P.; Eskander, M.F.; Gulhati, P.; In, H.; Kennedy, T.; Shah, M.M.; Grandhi, M.S.; Berim, L.; Spencer, K.R.; Langan, R.C.; Hochster, H.S.; Boland, P.M.; Jabbour, S.K. Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research. Curr. Oncol.2023, 30, 6432-6446.
Kumar, R.; Kim, J.; Deek, M.P.; Eskander, M.F.; Gulhati, P.; In, H.; Kennedy, T.; Shah, M.M.; Grandhi, M.S.; Berim, L.; Spencer, K.R.; Langan, R.C.; Hochster, H.S.; Boland, P.M.; Jabbour, S.K. Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research. Curr. Oncol. 2023, 30, 6432-6446.
Kumar, R.; Kim, J.; Deek, M.P.; Eskander, M.F.; Gulhati, P.; In, H.; Kennedy, T.; Shah, M.M.; Grandhi, M.S.; Berim, L.; Spencer, K.R.; Langan, R.C.; Hochster, H.S.; Boland, P.M.; Jabbour, S.K. Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research. Curr. Oncol.2023, 30, 6432-6446.
Kumar, R.; Kim, J.; Deek, M.P.; Eskander, M.F.; Gulhati, P.; In, H.; Kennedy, T.; Shah, M.M.; Grandhi, M.S.; Berim, L.; Spencer, K.R.; Langan, R.C.; Hochster, H.S.; Boland, P.M.; Jabbour, S.K. Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research. Curr. Oncol. 2023, 30, 6432-6446.
Abstract
The oncological outcomes are improving in gastrointestinal cancer with advancement in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT)to allow for further improvements in outcomes. Various preclinical and early phase II studies have shown promising synergy with immunotherapy and RT in gastrointestinal cancer. Consolidative nivolumab in esophageal cancer after neoadjuvant chemoradiation (CRT) and complete resection has recently been approved as standard treatment after improved disease free survival in phase III study. Immunotherapy has shown promising results in hepatocellular carcinoma and colorectal cancer as well. We have reviewed the published and ongoing studies of the combinations of immunotherapy and RT in gastrointestinal cancers.
Keywords
Immunotherapy; Radiation
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
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