Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dietary Manipulation of Amino Acids for Cancer Therapy

Version 1 : Received: 30 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (13:24:11 CEST)

A peer-reviewed article of this Preprint also exists.

Jiménez-Alonso, J.J.; López-Lázaro, M. Dietary Manipulation of Amino Acids for Cancer Therapy. Nutrients 2023, 15, 2879. Jiménez-Alonso, J.J.; López-Lázaro, M. Dietary Manipulation of Amino Acids for Cancer Therapy. Nutrients 2023, 15, 2879.

Abstract

Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs under challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted or supplemented with the 20 proteinogenic AAs, individually and in combinations. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers.

Keywords

cancer metabolism; anticancer activity; artificial diets; in vivo; mice; essential amino acids; non-essential amino acids; restriction; leucine; methionine; cysteine; arginine; serine; glutamine; asparagine

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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