Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cyanoacrylate in Colorectal Surgery: Is It Safe?

Anna D'Amore
* ORCID logo ,
Pietro Anoldo
ORCID logo ,
Michele Manigrasso
ORCID logo ,
Giovanni Aprea
,
Giovanni Domenico De Palma
,
Marco Milone
ORCID logo
Version 1 : Received: 29 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (08:45:57 CEST)

A peer-reviewed article of this Preprint also exists.

D’Amore, A.; Anoldo, P.; Manigrasso, M.; Aprea, G.; De Palma, G.D.; Milone, M. Cyanoacrylate in Colorectal Surgery: Is It Safe? J. Clin. Med. 2023, 12, 5152. D’Amore, A.; Anoldo, P.; Manigrasso, M.; Aprea, G.; De Palma, G.D.; Milone, M. Cyanoacrylate in Colorectal Surgery: Is It Safe? J. Clin. Med. 2023, 12, 5152.

Abstract

Anastomotic leakage (AL) after the creation of a gastrointestinal (GI) anastomosis remains an important complication in GI surgery. From its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide “prophylaxis” against AL. However although in surgical practice it is increasingly used, evidences on humans are still lacking. The aim of this study is to evaluate in humans the safety of CA to seal colorectal anastomosis. All consecutive patients from Jannuary 2022 through December 2022 who underwent minimally invasive colorectal surgery were retrospectively analysed from a prospectively maintained database. Inclusion criteria were histological diagnosis of cancer, totally minimally invasive procedure and absence of intraoperative complications. 103 patients were included in the study, N-butyl cyanoacrylate with metacryloxisulfolane (Glubran 2 ®) was used to seal colorectal anastomosis, no adverse reactions to CA or postoperative complications related to inflammation and adhesions occurred, only one case of AL (0.9%) was recorded. We can consider this study an important proof of concept on safety of CA to seal colorectal anastomosis. It opens the possibility to start performing prospective and comparative studies in humans to evaluate effectiveness of CA in preventing colorectal AL.

Keywords

Cyanoacrylate; anastomosis; leakage; inflammation; adhesions.

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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