Potential Immunotherapy of Dendritic Cell-Cytokine-Induced Killer Cells for Refractory Metastatic Colorectal Cancer: A Preliminary Experience of Single Tertiary Hospital

How to cite: Ke, T.; Huang, C.; Chang, S.; Huang, W.; Hsu, C.; Tsai, C.; Chen, C.; Lin, C.; Yip, H.; Cho, D.; Tsai, C.; Chen, W.T.; Shyu, W.; Jeng, L. Potential Immunotherapy of Dendritic Cell-Cytokine-Induced Killer Cells for Refractory Metastatic Colorectal Cancer: A Preliminary Experience of Single Tertiary Hospital. Preprints 2023, 2023051971. https://doi.org/10.20944/preprints202305.1971.v1 Ke, T.; Huang, C.; Chang, S.; Huang, W.; Hsu, C.; Tsai, C.; Chen, C.; Lin, C.; Yip, H.; Cho, D.; Tsai, C.; Chen, W.T.; Shyu, W.; Jeng, L. Potential Immunotherapy of Dendritic Cell-Cytokine-Induced Killer Cells for Refractory Metastatic Colorectal Cancer: A Preliminary Experience of Single Tertiary Hospital. Preprints 2023, 2023051971. https://doi.org/10.20944/preprints202305.1971.v1

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MDPI and ACS Style

Ke, T.; Huang, C.; Chang, S.; Huang, W.; Hsu, C.; Tsai, C.; Chen, C.; Lin, C.; Yip, H.; Cho, D.; Tsai, C.; Chen, W.T.; Shyu, W.; Jeng, L. Potential Immunotherapy of Dendritic Cell-Cytokine-Induced Killer Cells for Refractory Metastatic Colorectal Cancer: A Preliminary Experience of Single Tertiary Hospital. Preprints 2023, 2023051971. https://doi.org/10.20944/preprints202305.1971.v1

APA Style

Ke, T., Huang, C., Chang, S., Huang, W., Hsu, C., Tsai, C., Chen, C., Lin, C., Yip, H., Cho, D., Tsai, C., Chen, W.T., Shyu, W., & Jeng, L. (2023). Potential Immunotherapy of Dendritic Cell-Cytokine-Induced Killer Cells for Refractory Metastatic Colorectal Cancer: A Preliminary Experience of Single Tertiary Hospital. Preprints. https://doi.org/10.20944/preprints202305.1971.v1

Chicago/Turabian Style

Ke, T., Woei-Cherng Shyu and Long-Bin Jeng. 2023 "Potential Immunotherapy of Dendritic Cell-Cytokine-Induced Killer Cells for Refractory Metastatic Colorectal Cancer: A Preliminary Experience of Single Tertiary Hospital" Preprints. https://doi.org/10.20944/preprints202305.1971.v1

Abstract

Background Successful treatment for patients with metastatic colorectal cancer who failed to response to first-line treatment has been a challenge due to their low response rate for later-line treatment and poor progression free survival and overall survival. The application of dendritic cell-cytokine-induced killer cells (DC-CIK) immunotherapy combined with conventional treat-ment, either surgical resection or chemotherapy, showed improvement in survivals in first-line treatment for metastatic colorectal cancer. In this retrospective study, we aimed to evaluate the benefit of dendritic cell-cytokine-induced killer cells (DC-CIK) immunotherapy for patient with refractory metastatic colorectal cancer. Methods A total of 20 patients with refractory metastatic colorectal cancer receiving cell-cytokine-induced killer cells (DC-CIK) immunotherapy were enrolled to this study. Among these patients, 11 patients responded to the treatment and the remaining 9 patients did not. All patients were followed for at least one years and the determination of treatment response was mainly based on image study at 6 months after the completion of treatment. Data were analyzed with Kaplan-Meier method and log-rank test. Results The treatment response rate of the study group is 55% (11/20). The median progression free sur-vival (PFS) and median overall survival (OS) of responsive patients was 7 months and 12 months, respectively. The median overall survival of irresponsive patients was 9.5 months. Four responsive patients received subsequent metastectomy or cytoreduction plus hyperthermic in-traperitoneal chemotherapy surgery (CRS + HIPEC). Conclusion DC-CIK cell-based immunotherapy may provide benefits for patients with refractory mCRC with improved response rate and progression free survival.

Keywords

DC-CIK; immunotherapy; colorectal cancer

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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