Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chemical Characterization, Antilipidemic Effect and Antiobesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome

Version 1 : Received: 25 May 2023 / Approved: 26 May 2023 / Online: 26 May 2023 (04:40:32 CEST)

A peer-reviewed article of this Preprint also exists.

Morales-Ferra, D.L.; Zavala-Sánchez, M.Á.; Jiménez-Ferrer, E.; Trejo-Moreno, C.; González-Cortazar, M.; Gamboa-Gómez, C.I.; Guerrero-Romero, F.; Zamilpa, A. Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome. Plants 2023, 12, 2578. Morales-Ferra, D.L.; Zavala-Sánchez, M.Á.; Jiménez-Ferrer, E.; Trejo-Moreno, C.; González-Cortazar, M.; Gamboa-Gómez, C.I.; Guerrero-Romero, F.; Zamilpa, A. Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome. Plants 2023, 12, 2578.

Abstract

Ludwigia octovalvis (Jacq.) P.H. Raven is widely used in traditional medicine for different illnesses included diabetes and hypertension. However, its impact on lipotoxicity and metabolic syndrome in vivo has not been addressed. Therefore, the aim of this study was to evaluate the effects of this plant on the metabolic syndrome parameters in a C57BL6J mouse hypercaloric diet model. L. octovalvis hydroalcoholic extract and its ethyl acetate fraction (25 mg/kg/day) were used for sub-chronic assessment (10 weeks). Also four subfractions (25 mg/kg) were evaluated in the postprandial triglyceridemia test in healthy C57BL6J mice. The hydroalcoholic extract and ethyl acetate fraction significantly decreased body weight gain (-6.9 g and -1.5 g), fasting glycemia (-46.1 and -31.2 mg/dL), systolic (-26.0 and -22.5mmHg) and diastolic (-8.1 and 16.2 mmHg) blood pressure, free fatty acid concentration (-13.8 and -8.0 μg/mL) and insulin-resistance (measured by TyG index, -0.207 and -0.18) compared to the negative control. Postprandial triglyceridemia test showed that the effects in the sub-chronic model are due, at least in part, to improvement in this parameter. L. octovalvis treatments, particularly the hydroalcoholic extract, improve MS alterations and decrease free fatty acid concentration. These effects are possibly due to high contents of corilagin and ellagic acid.

Keywords

Metabolic syndrome; hypercaloric diet; FFA; Ludwigia; corilagin; ellagic acid; gallic acid

Subject

Chemistry and Materials Science, Medicinal Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.