Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle

Version 1 : Received: 23 May 2023 / Approved: 24 May 2023 / Online: 24 May 2023 (05:00:56 CEST)

A peer-reviewed article of this Preprint also exists.

Yu, J.-D.; Yu, D.-D.; Su, M.-Z.; Gu, Y.-C.; Wang, H.; Guo, Y.-W. New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle. Mar. Drugs 2023, 21, 362. Yu, J.-D.; Yu, D.-D.; Su, M.-Z.; Gu, Y.-C.; Wang, H.; Guo, Y.-W. New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle. Mar. Drugs 2023, 21, 362.

Abstract

Fifteen new diterpenoids, namely xishaklyanes A-O (1-15), along with three known related ones (16-18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds were elucidated by a combination of detailed spectroscopic analyses, chemical syntheses, quantum chemical calculations and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher's method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 g/mL against Lactococcus garvieae.

Keywords

Soft coral; Klyxum molle; Diterpenoids; Stereochemistry; Antibacterial activity

Subject

Chemistry and Materials Science, Medicinal Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.