Villanacci, V.; Del Sordo, R.; Parigi, T.L.; Leoncini, G.; Bassotti, G. Inflammatory Bowel Diseases: Does One Histological Score Fit All? Diagnostics2023, 13, 2112.
Villanacci, V.; Del Sordo, R.; Parigi, T.L.; Leoncini, G.; Bassotti, G. Inflammatory Bowel Diseases: Does One Histological Score Fit All? Diagnostics 2023, 13, 2112.
Villanacci, V.; Del Sordo, R.; Parigi, T.L.; Leoncini, G.; Bassotti, G. Inflammatory Bowel Diseases: Does One Histological Score Fit All? Diagnostics2023, 13, 2112.
Villanacci, V.; Del Sordo, R.; Parigi, T.L.; Leoncini, G.; Bassotti, G. Inflammatory Bowel Diseases: Does One Histological Score Fit All? Diagnostics 2023, 13, 2112.
Abstract
Mucosal healing (MH) is the main treatment target in ulcerative colitis and Crohn’s disease, and it is defined by a combination of complete endoscopic and histologic remission. Indeed, the complete resolution of mucosal inflammation should be confirmed at histology. Neutrophil infiltration represents the unique histological marker in discriminating the active vs quiescent phase of disease, also including crypt injuries (cryptitis and crypt abscesses), erosions and ulcerations. Basal plasmacytosis do not qualify by itself the remission in inflammatory bowel diseases (IBD), but it represents a diagnostic clue, mostly at onset. Several histological scoring systems have been developed to evaluate therapeutic efficacy, even though they often resulted tricky and subjective. Moreover, these scores listed a heterogeneous group of histological features as parameters. The recently proposed simplified histological score on MH was based on neutrophils and their distribution in the gut mucosa was also considered, aiming to provide a simple, time-sparing and reproducible tool to be applied to the routinary diagnostic practice. The artificial intelligence could be a promising tool both in evaluating and standardizing the histological assessment of disease activity in IBD. Moreover, novel molecules involved in the inflammatory dynamics in the gut could be employed in supporting the diagnostic practice in IBD.
Medicine and Pharmacology, Gastroenterology and Hepatology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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