Cavalcante-Silva, L.H.A.; Almeida, F.S.; Andrade, A.G.; Comberlang, F.C.; Cardoso, L.L.; Vanderley, S.E.R.; Keesen, T.S.L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis. Int. J. Mol. Sci.2023, 24, 11385.
Cavalcante-Silva, L.H.A.; Almeida, F.S.; Andrade, A.G.; Comberlang, F.C.; Cardoso, L.L.; Vanderley, S.E.R.; Keesen, T.S.L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis. Int. J. Mol. Sci. 2023, 24, 11385.
Cavalcante-Silva, L.H.A.; Almeida, F.S.; Andrade, A.G.; Comberlang, F.C.; Cardoso, L.L.; Vanderley, S.E.R.; Keesen, T.S.L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis. Int. J. Mol. Sci.2023, 24, 11385.
Cavalcante-Silva, L.H.A.; Almeida, F.S.; Andrade, A.G.; Comberlang, F.C.; Cardoso, L.L.; Vanderley, S.E.R.; Keesen, T.S.L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis. Int. J. Mol. Sci. 2023, 24, 11385.
Abstract
Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target.
Keywords
NETs; innate immunity; mycobacteria.
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.