Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis

Version 1 : Received: 22 May 2023 / Approved: 23 May 2023 / Online: 23 May 2023 (05:30:13 CEST)

A peer-reviewed article of this Preprint also exists.

Cavalcante-Silva, L.H.A.; Almeida, F.S.; Andrade, A.G.; Comberlang, F.C.; Cardoso, L.L.; Vanderley, S.E.R.; Keesen, T.S.L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis. Int. J. Mol. Sci. 2023, 24, 11385. Cavalcante-Silva, L.H.A.; Almeida, F.S.; Andrade, A.G.; Comberlang, F.C.; Cardoso, L.L.; Vanderley, S.E.R.; Keesen, T.S.L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis. Int. J. Mol. Sci. 2023, 24, 11385.

Abstract

Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target.

Keywords

NETs; innate immunity; mycobacteria.

Subject

Biology and Life Sciences, Immunology and Microbiology

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