Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exploring the Impact of Herbal Therapies on COVID-19 and Influenza: Investigating Novel Delivery Mechanisms for Emerging Interventions

Lucas Fornari Laurindo
ORCID logo ,
Ledyane Taynara Marton
,
Giulia Minniti
ORCID logo ,
Victoria Dogani Rodrigues
,
Rodrigo Buzinaro Suzuki
,
Virgínia Maria Cavallari Strozze Catharin
,
Rakesh Kumar Joshi
,
Sandra Maria Barbalho
* ORCID logo
Version 1 : Received: 9 May 2023 / Approved: 11 May 2023 / Online: 11 May 2023 (08:30:22 CEST)

How to cite: Fornari Laurindo, L.; Taynara Marton, L.; Minniti, G.; Dogani Rodrigues, V.; Buzinaro Suzuki, R.; Maria Cavallari Strozze Catharin, V.; Joshi, R.K.; Barbalho, S.M. Exploring the Impact of Herbal Therapies on COVID-19 and Influenza: Investigating Novel Delivery Mechanisms for Emerging Interventions. Preprints.org 2023, 2023050822. https://doi.org/10.20944/preprints202305.0822.v1 Fornari Laurindo, L.; Taynara Marton, L.; Minniti, G.; Dogani Rodrigues, V.; Buzinaro Suzuki, R.; Maria Cavallari Strozze Catharin, V.; Joshi, R.K.; Barbalho, S.M. Exploring the Impact of Herbal Therapies on COVID-19 and Influenza: Investigating Novel Delivery Mechanisms for Emerging Interventions. Preprints.org 2023, 2023050822. https://doi.org/10.20944/preprints202305.0822.v1

Abstract

Synthetic antivirals and corticosteroids have been used to treat both influenza and the SARS-CoV-2 disease named COVID-19. However, these medications are not always effective, produce several adverse effects, and are associated with high costs. Medicinal plants and their constituents act in several different targets and signaling pathways involved in the pathophysiology of Influenza and COVID-19. This study aimed to perform a review to evaluate the effects of medicinal plants on Influenza and COVID-19 and to investigate the potential delivery systems for new antiviral therapies. EMBASE, PubMed, GOOGLE SCHOLAR, and COCHRANE databases were searched. The studies included in this review showed that medicinal plants, in different formulations, can help decrease viral spread and time of full recovery. Plants reduced the incidence of acute respiratory syndromes and the symptom scores of the illnesses. Moreover, plants are related to few adverse effects and have low costs. In addition to their significance as natural antiviral agents, medicinal plants and their bioactive compounds may exhibit low bioavailability. This highlights the need for alternative delivery systems, such as metal nanoparticles, that can effectively transport these compounds to infected tissues.

Keywords

Medicinal plants; antiviral; SARS-CoV-2; COVID-19; Influenza; Delivery systems; Nanomedicine; Nanocarriers; Antiviral therapies

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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