Version 1
: Received: 10 May 2023 / Approved: 10 May 2023 / Online: 10 May 2023 (14:25:14 CEST)
Version 2
: Received: 15 June 2023 / Approved: 16 June 2023 / Online: 16 June 2023 (10:38:50 CEST)
Hardy, E.; Sarker, H.; Fernandez-Patron, C. Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity? Cells2023, 12, 1699.
Hardy, E.; Sarker, H.; Fernandez-Patron, C. Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity? Cells 2023, 12, 1699.
Hardy, E.; Sarker, H.; Fernandez-Patron, C. Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity? Cells2023, 12, 1699.
Hardy, E.; Sarker, H.; Fernandez-Patron, C. Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity? Cells 2023, 12, 1699.
Abstract
We advance the notion that much, like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria and other microorganisms) may also acquire a biomolecular corona, upon entering the blood circulation of an organism. We view this biomolecular corona as a component of a much broader non-cellular blood interactome that can be highly specific to the organism, akin to components of the innate immune response to an invading pathogen. We review published supporting data and generalize these notions from artificial nanoparticles to viruses and bacteria. Characterization of the non-cellular blood interactome of an organism may help explain apparent differences in the susceptibility to pathogens among individuals. The non-cellular blood interactome is a candidate therapeutic target to treat infectious and non-infectious conditions.
Keywords
Nanoparticles; virus; bacteria; protein corona; glucocorticoid; innate immunity
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
