Zanotti, L.C.; Malizia, F.; Cesatti Laluce, N.; Avila, A.; Mamberto, M.; Anselmino, L.E.; Menacho-Márquez, M. Synuclein Proteins in Cancer Development and Progression. Biomolecules2023, 13, 980.
Zanotti, L.C.; Malizia, F.; Cesatti Laluce, N.; Avila, A.; Mamberto, M.; Anselmino, L.E.; Menacho-Márquez, M. Synuclein Proteins in Cancer Development and Progression. Biomolecules 2023, 13, 980.
Zanotti, L.C.; Malizia, F.; Cesatti Laluce, N.; Avila, A.; Mamberto, M.; Anselmino, L.E.; Menacho-Márquez, M. Synuclein Proteins in Cancer Development and Progression. Biomolecules2023, 13, 980.
Zanotti, L.C.; Malizia, F.; Cesatti Laluce, N.; Avila, A.; Mamberto, M.; Anselmino, L.E.; Menacho-Márquez, M. Synuclein Proteins in Cancer Development and Progression. Biomolecules 2023, 13, 980.
Abstract
Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in certain tumors. Since their discovery, tens of thousands of scientific reports have been published about this family of proteins as they are associated to severe human diseases. Although the physiological function of these proteins still elusive, their relation with neurodegeneration and cancer was clearly described over the years. In this review, we summarize data connecting synucleins and cancer, going from the structural description of these molecules, to their involvement in tumor-related processes, and discuss the putative use of this proteins as cancer molecular biomarkers.
Biology and Life Sciences, Biochemistry and Molecular Biology
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