Wang, C.; Kim, I.-J.; Seong, H.-R.; Noh, C.H.; Park, S.; Kim, T.M.; Jeong, H.S.; Kim, K.Y.; Kim, S.T.; Yuk, H.-G.; Kwon, S.-C.; Choi, E.-K.; Kim, Y.-B. Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses. Nutrients2023, 15, 2376.
Wang, C.; Kim, I.-J.; Seong, H.-R.; Noh, C.H.; Park, S.; Kim, T.M.; Jeong, H.S.; Kim, K.Y.; Kim, S.T.; Yuk, H.-G.; Kwon, S.-C.; Choi, E.-K.; Kim, Y.-B. Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses. Nutrients 2023, 15, 2376.
Wang, C.; Kim, I.-J.; Seong, H.-R.; Noh, C.H.; Park, S.; Kim, T.M.; Jeong, H.S.; Kim, K.Y.; Kim, S.T.; Yuk, H.-G.; Kwon, S.-C.; Choi, E.-K.; Kim, Y.-B. Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses. Nutrients2023, 15, 2376.
Wang, C.; Kim, I.-J.; Seong, H.-R.; Noh, C.H.; Park, S.; Kim, T.M.; Jeong, H.S.; Kim, K.Y.; Kim, S.T.; Yuk, H.-G.; Kwon, S.-C.; Choi, E.-K.; Kim, Y.-B. Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses. Nutrients 2023, 15, 2376.
Abstract
Oxidative stress and inflammation are basic pathogenic factors involved in tissue injury, pain, as well as acute and chronic diseases. Since long-term uses of steroids and non-steroidal anti-inflammatory drugs (NSAIDs) cause severe adverse effects, novel effective materials with minimal side effects are required. In this study, polyphenol content and antioxidative activity of rosebud extracts from 24 newly-crossbred Korean roses were analyzed. Among them, Pretty Velvet rosebud extract (PVRE) were found to contain high polyphenols and to show in vitro antioxidative and anti-inflammatory activities. In RAW 264.7 cells stimulated with lipopolysaccharide (LPS), PVRE down-regulated mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and thereby decreased nitric oxide (NO) and prostaglandin E2 (PGE2) production. In an air-pouch inflammation model, treatment with PVRE decreased λ-carrageenan-induced tissue exudation, infiltration of inflammatory cells including neutrophils, monocytes and lymphocytes, and tumor necrosis factor-α and interleukin-1β concentrations, as achieved with dexamethasone (a steroid). Notably, PVRE also inhibited PGE2, similar to dexamethasone and indomethacin (an NSAID). The anti-inflammatory effects of PVRE were confirmed by microscopic findings, attenuating tissue erythema, edema, and inflammatory cell infiltration. These results indicate that PVRE exhibits dual (steroid- and NSAID-like) anti-inflammatory activities by blocking both the iNOS ― NO and COX-2 ― PG pathways, and that PVRE could be a promising anti-inflammatory material for diverse issue injuries.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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