Levichkina, E.; Pigarev, I.N.; Grayden, D.B.; Petrou, S.; Vidyasagar, T.R. Sleep Links Hippocampal Propensity for Epileptiform Activity to Its Viscerosensory Inputs. Preprints2023, 2023050064. https://doi.org/10.20944/preprints202305.0064.v1
APA Style
Levichkina, E., Pigarev, I.N., Grayden, D.B., Petrou, S., & Vidyasagar, T.R. (2023). Sleep Links Hippocampal Propensity for Epileptiform Activity to Its Viscerosensory Inputs. Preprints. https://doi.org/10.20944/preprints202305.0064.v1
Chicago/Turabian Style
Levichkina, E., Steven Petrou and Trichur R Vidyasagar. 2023 "Sleep Links Hippocampal Propensity for Epileptiform Activity to Its Viscerosensory Inputs" Preprints. https://doi.org/10.20944/preprints202305.0064.v1
Abstract
Seizure development relies on two factors. One is the existence of an overexcitable neuronal network and the other is a trigger that switches normal activity of that network into a paroxysmal state. While mechanisms of local overexcitation have been the focus of many studies, the process of triggering remains poorly understood. We suggest that, apart from the known exteroceptive sources of reflex epilepsy – visual, auditory or olfactory, there is a range of interoceptive triggers, relevant for seizure development in Temporal Lobe Epilepsy (TLE). The hypothesis proposed here aims to explain the prevalence of epileptic activity in sleep and in drowsiness states and provide a detailed mechanism of seizure triggering by interoceptive signals.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
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