Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Mapping of Allergen Exposome Among Different Atopic Phenotypes

Version 1 : Received: 1 May 2023 / Approved: 2 May 2023 / Online: 2 May 2023 (01:50:56 CEST)

A peer-reviewed article of this Preprint also exists.

González-Pérez, R.; Poza-Guedes, P.; Pineda, F.; Galán, T.; Mederos-Luis, E.; Abel-Fernández, E.; Martínez, M.J.; Sánchez-Machín, I. Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes. Int. J. Mol. Sci. 2023, 24, 10467. González-Pérez, R.; Poza-Guedes, P.; Pineda, F.; Galán, T.; Mederos-Luis, E.; Abel-Fernández, E.; Martínez, M.J.; Sánchez-Machín, I. Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes. Int. J. Mol. Sci. 2023, 24, 10467.

Abstract

Climate change and exposure to environmental pollutants play a key role in the onset and aggravation of allergic diseases. As different climate-dependent patterns of molecular immunoglobulin E (IgE) reactivity have been regionally described, we sought to investigate the evolving allergen exposome in distinctive allergic phenotypes, and subtropical weather conditions through a Precision Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several house dust mites (HDM) and storage mite molecules were broadly dominant in the investigated cohort, followed by the major cat allergen Fel d 1, and regardless of the basal allergic disease. Although a complex repertoire of allergens was recognized, a steadily increasing number of IgE binding molecules was associated with the complexity of the underlying atopic disease. Besides the highly prevalent IgE responses to HMD major allergens, Der p 21, Der p 5, and Der p 7 also showed as serodominant molecules, especially in those subjects bothered with asthma and atopic dermatitis. The accurate characterization of the external exposome at the molecular level and their putative role as clinically relevant allergens is essential to elucidate the phenotypic diversity of atopic disease in terms of personalized diagnosis and therapy.

Keywords

Airborne allergens; Exposome; Climate change; Atopy; Allergic rhinitis; Asthma; Atopic dermatitis

Subject

Medicine and Pharmacology, Immunology and Allergy

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