Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Impact of Blood Flow Restricted Training on Arterial Functions and Angiogenesis: A Systematic Review With Meta-analysis

Mikołaj Maga
ORCID logo ,
Agnieszka Wachsmann-Maga
,
Krzysztof Batko
,
Aleksandra Włodarczyk
,
Paulina Kłapacz
,
Jakub Krężel
,
Natalia Szopa
,
Agnieszka Śliwka
* ORCID logo
Version 1 : Received: 30 April 2023 / Approved: 1 May 2023 / Online: 1 May 2023 (10:39:55 CEST)

A peer-reviewed article of this Preprint also exists.

Maga, M.; Wachsmann-Maga, A.; Batko, K.; Włodarczyk, A.; Kłapacz, P.; Krężel, J.; Szopa, N.; Sliwka, A. Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis. Biomedicines 2023, 11, 1601. Maga, M.; Wachsmann-Maga, A.; Batko, K.; Włodarczyk, A.; Kłapacz, P.; Krężel, J.; Szopa, N.; Sliwka, A. Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis. Biomedicines 2023, 11, 1601.

Abstract

Blood flow-restricted training (BFR) is constantly growing in popularity. Despite growing evidence of the significant influence of BFR training on different body functions, its impact on the vascular system, especially the arteries, is controversial. Therefore, the objective of our study was to analyze how BFR exercise, compared to other types of exercise without restriction of blood flow or other active intervention, influences arterial functions and angiogenesis in adults. Studies comparing the effect of BFR versus non-BFR training on arterial parameters are divided into three categories. Endothelial function, angiogenesis, and other vasculature functions. The search was based on three databases (Cochrane Library, PubMed®, Embase). In this systematic review, 38 studies were included. Meta-analysis revealed a more significant improvement in flow-mediated dilatation (FMD) (p=0.002) and the production of the primary angiogenesis biomarker Vascular Endothelial Growth Factor (VEGF) (p=0.009) after training in BFR compared to nonBFR (p=0.002). Analysis of pulse wave velocity, ankle-brachial index, systolic blood pressure, or heart rate did not show a significant difference in changes between BFR and non-BFR training. Other parameters examined were not sufficiently provided to be included in the meta-analysis. The results obtained, present trends suggesting the significant impact of BFR training on endothelial functions and angiogenesis. Unfortunately, there is still a lack of multicenter randomized clinical trials, including many participants, that are necessary to confirm the advantage of BFR over non-BFR activity.

Keywords

blood flow restricted training; vascular functions; angiogenesis; endothelium

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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