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† These authors have same contributions as the first author.
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27 April 2023
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27 April 2023
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NO | Keyword | Occurrences | Total link strength | NO | Keyword | Occurrences | Total link strength |
---|---|---|---|---|---|---|---|
1 | Treatment outcome | 44 | 255 | 11 | Immunohistochemistry | 21 | 120 |
2 | Creatinine | 43 | 247 | 12 | Liver | 20 | 105 |
3 | Ischemia | 36 | 194 | 13 | Malondialdehyde | 20 | 109 |
4 | Time factors | 36 | 206 | 14 | Superoxide dismutase | 20 | 105 |
5 | Double-blind method | 35 | 204 | 15 | Protective agents | 19 | 100 |
6 | Biomarkers | 34 | 209 | 16 | Blood urea nitrogen | 18 | 89 |
7 | Apoptosis | 29 | 157 | 17 | Antioxidants | 17 | 84 |
8 | Oxidative stress | 29 | 187 | 18 | Lung | 17 | 80 |
9 | Ischemic preconditioning | 28 | 150 | 19 | Kidney diseases | 15 | 57 |
10 | Nephrectomy | 23 | 119 | 20 | Tumor necrosis factor-alpha | 15 | 84 |
NO | Author | Documents | Total link strength | Average publication year |
---|---|---|---|---|
1 | Brito, Marcus Vinicius Henriques | 5 | 35 | 2016 |
2 | Barakat, Nashwa | 3 | 8 | 2011 |
3 | Corso, Carlos Otávio | 3 | 21 | 2015 |
4 | Costa, Felipe Lobato Da Silva | 3 | 19 | 2016 |
5 | Gomes, Regina De Paula Xavier | 3 | 13 | 2015 |
6 | Guven, Ahmet | 3 | 21 | 2008 |
7 | Hausenloy, Derek J | 3 | 31 | 2014 |
8 | Hussein, Abdel-Aziz M | 3 | 8 | 2011 |
9 | Korkmaz, Ahmet | 3 | 21 | 2008 |
10 | Santos, Emanuel Burck Dos | 3 | 21 | 2015 |
NO | Author | Link | Total Link Strength |
---|---|---|---|
1 | Brito, Marcus Vinicius Henriques | 22 | 35 |
2 | Hausenloy, Derek J | 27 | 31 |
3 | Ariti, Cono | 19 | 23 |
4 | Candilio, Luciano | 19 | 23 |
5 | Kolvekar, Shyam | 19 | 23 |
6 | Yellon, Derek M | 19 | 23 |
7 | Van Leeuwen, Paul A M | 14 | 22 |
8 | Van Norren, Klaske | 14 | 22 |
9 | Gaber, A Osama | 21 | 22 |
10 | Hemmerich, Stefan | 21 | 22 |
Keyword | Occurrences | Total link strength | Average publication year | Their role in IRI | References |
---|---|---|---|---|---|
Ligands | |||||
Benzodioxole | 1 | 4 | 2018 | Amelioration | [28] |
Eplerenone | 1 | 8 | 2018 | Amelioration | [29] |
Hydrocortisone | 1 | 9 | 2018 | Amelioration | [30] |
Indoles | 1 | 5 | 2019 | Amelioration | [31] |
Nicotinamide adenine dinucleotide | 1 | 13 | 2021 | Amelioration | [32] |
Niacinamide | 1 | 13 | 2021 | Amelioration | [33] |
Receptors | |||||
Aldehyde dehydrogenase, mitochondrial | 1 | 4 | 2018 | Amelioration | [34] |
Mineralocorticoid receptor antagonists | 1 | 8 | 2018 | Amplification | [35] |
TNF receptor-associated factor 6 | 1 | 5 | 2018 | Amplification | [36] |
Estrogen receptor alpha | 1 | 5 | 2018 | Amelioration | [37] |
Toll-like receptor 4 | 1 | 5 | 2018 | Amplification | [38] |
Myeloid differentiation factor 88 | 1 | 5 | 2018 | Amplification | [39] |
Glucuronidase | 2 | 26 | 2020 | Amelioration | [40] |
Klotho proteins | 2 | 26 | 2020 | Amelioration | [41] |
Sirtuin 1 | 1 | 13 | 2021 | Amelioration | [42] |
Ligands | Receptors | ||||||||
---|---|---|---|---|---|---|---|---|---|
AD* | ER | Glucuronidase | Klotho protein | MR | MDF | Sirtuin 1 | TLR4 | TNFR | |
Benzodioxole | -5.5 | -5.7 | -6.2 | -6.2 | -6.2 | -5.4 | -6.2 | -3.9 | -5.4 |
Eplerenone | -13.4 | -12.9 | -11.3 | -11.7 | -12.6 | -9.2 | -11.7 | -8.8 | -9.0 |
Hydrocortisone | -12.3 | -11.6 | -11.5 | -10.5 | -11.5 | -8.6 | -11.6 | -8.4 | -8.6 |
Indole-3-acetic acid | -6.6 | -7.0 | -8.1 | -7.8 | -7.3 | -6.1 | -7.1 | -5.4 | -5.3 |
Nicotinamide | -5.9 | -5.6 | -6.3 | -5.8 | -5.7 | -4.8 | -5.7 | -4.0 | -5.3 |
NAD | -12.5 | -11.6 | -12.1 | -11.5 | -10.4 | -10.6 | -10.8 | -7.3 | -11.0 |
Method | Patients/Model | Effects | References |
---|---|---|---|
Local cooling of the kidney graft using a plastic bag filled with ice. | 23 patients | Long-term maintenance of optimally low temperature during kidney vascular anastomoses to reduce the negative effects of WIT, such as a low frequency of DGF and acute rejection, and optimal GFR after surgery. | [22] |
Local cooling of the pelvis using ice slush during robotic kidney transplantation. | 7 patients | Local cooling during vascular anastomoses to reduce the negative effects of WIT. | [43] |
A controllable double-cycle cryogenic device with a circulating cooling system (cold saline solution: 0-4°C) and warming system (warm sterile water: 30-35°C). | 20 pigs | Local cooling of the renal graft during vascular anastomoses to reduce the negative effects of WIT with simultaneous warming of the peritoneum and lumbar muscles. | [44] |
Net-restrictive plastic jacket with a circulating cooling system that uses saline solution at a temperature of 0-4°C. | 9 patients | Local cooling of the renal graft during vascular anastomoses to reduce the negative effects of WIT. | [45] |
Intra-abdominal cooling device with double silicone sheaths for continuous circulation of 4°C ethanol and methylene blue during open kidney transplantation. | 13 pigs | Local cooling of the renal graft during vascular anastomoses by continuously circulating 4°C ethanol and methylene blue to reduce the negative effects of WIT. | [46] |
Intra-abdominal cooling device with double silicone sheaths for continuous circulation of 4°C ethanol and methylene blue during robotic kidney transplantation. | 23 pigs | Local cooling of the renal graft during vascular anastomoses by continuously circulating 4°C ethanol and methylene blue to reduce the negative effects of WIT. | [47] |
A cooling device for the kidney graft made of thermal insulation materials with a cold saline circulation system. | 6 pigs 5 patients |
Long-term maintenance of optimal temperature (10-15°C) during vascular anastomoses to reduce the negative effects of WIT. | [48] |
A thermally insulating jacket for the kidney. | 5 pigs | Long-term maintenance of optimal temperature (0-15°C) during vascular anastomoses to reduce the negative effects of WIT. | [49] |
An ice bag for placing the kidney transplant during implantation. | 66 patients | Local cooling of the renal graft during vascular anastomoses to reduce the negative effects of WIT. | [50] |
Kidney cooling with Ringer's solution through the renal artery with drainage through an incision in the renal vein during robotic laparoscopic resection. | 37 patients | Local intraparenchymal cooling of the kidney during its resection to reduce the negative effects of WIT. | [51] |
Continuous retrograde cooling of the kidney with irrigated cold saline solution (1.0-1.3°C) through the ureter during ischemia. | 6 pigs | Renal pelvis continuous local cooling during clamping of the renal artery to reduce the negative effects of WIT. | [52] |
Continuous retrograde cooling of the kidney during resection with irrigated cold saline solution through a catheterized ureter. | 10 patients | Renal pelvis local cooling of the kidney during ischemia to reduce the negative effects of WIT. | [53] |
Gradual controlled increase in kidney temperature by machine perfusion (from 4°C to 20°C) after cold ischemia and before reperfusion. | 12 pigs | A gradual increase of the renal temperature before reperfusion reduces mitochondrial dysfunction and apoptosis after kidney reperfusion by half. | [16] |
Hydrodynamic fluid injection into the renal vein (retrograde) after ischemia and reperfusion. | 5 rats | Retrograde fluid injection improves microcirculation after ischemia and reperfusion, reduces inflammatory cell infiltration of parenchyma, and leads to a rapid recovery of renal function. | [54] |
Capsulotomy of the kidney after cold and warm ischemia. | 8 pigs | Reduction of intraparenchymal pressure and elimination of compartment syndrome after reperfusion to improve the structural and functional condition of the transplanted kidney. | [55] |
Microcapsulotomy after ischemia and reperfusion. | 13 mice | Reducing the severity of compartment syndrome of the transplanted kidney to improve its structural and functional condition. | [56] |
Microcapsulotomy in combination with the introduction of endothelial stem cells. | 29 mice | Combination therapy reduces morphological damage to the kidneys (tubules), infiltration of macrophages, and increases the index of proliferation and regeneration. | [57] |
Intraoperative increase of blood pressure in the kidney. | 106 patients | Maintenance of arterial blood pressure ≥150 mmHg before and during reperfusion improves microcirculation of the kidney and is associated with early stabilization of its function. | [58] |
Intraoperative splenic ischemic preconditioning before kidney implantation. | 18 rats | Reduction of the release of inflammatory mediators and effective reduction of serum creatinine levels. | [59] |
Remote ischemic preconditioning of the lower limb before organ ischemia. | 18 rats | Activation of antioxidant protection of liver and kidney cells during ischemia. | [60] |
Intraabdominal administration of MSCs after ischemia and reperfusion of both kidneys. | 18 rats | Improvement of kidney function after ischemia-reperfusion injury by reducing inflammatory and oxidative reactions. | [61] |
Introduction of MSCs into the renal artery and renal vein after ischemia and reperfusion of the kidney. | 10 rats | Improvement of kidney function in ischemia-reperfusion injury, reduction of renal tissue fibrosis, and induced IRI. | [62] |
Introduction of own venous blood (1 ml) into the renal artery before kidney reperfusion. | 30 rabbits | Venous blood reduces the production of reactive oxygen species and has an antioxidant effect on renal tissue after ischemia and reperfusion. | [63] |
Type | Method | Pros | Cons | Author |
---|---|---|---|---|
Local kidney cooling by a closed system | Local cooling of the kidney graft with a plastic bag with ice (23 patients) |
|
|
[22] |
Local cooling of the pelvis with ice slush during robotic kidney transplantation (7 patients) |
|
|
[43] | |
A controllable double-cycle cryogenic device with circulating cooling (cold saline solution: 0-4°C) and warming (warm sterile water: 30-35°C) system (20 pigs) |
|
|
[44] | |
Net-restrictive plastic jacket with circulating cooling system by saline solution at a temperature of 0-4°C (9 patients) |
|
|
[45] | |
Intra-abdominal cooling device with double silicone sheaths for continuously circulating of 4°C ethanol and methylene blue in open kidney transplantation (13 pigs) |
|
|
[46] | |
Intra-abdominal cooling device with double silicone sheaths for continuously circulating of 4°C ethanol and methylene blue in robotic kidney transplantation (23 pigs) |
|
|
[47] | |
Cooling device for kidney graft made of thermal insulation materials with cold saline circulation system (6 pigs – phase #0; 5 patients – phase #1) |
|
|
[48] | |
Thermally insulating jacket for kidney (5 pigs) |
|
|
[49] | |
An ice bag for placing a kidney transplant during implantation (66 patients) |
|
|
[50] | |
Local cooling of the kidney with cold solution irrigation or ice slush during its laparoscopic resection (Review) |
|
|
[69] | |
Continuous retrograde cooling of the kidney with irrigated cold saline solution (1.0-1.3°C) through the ureter during ischemia (Pig model) |
|
|
[52] | |
Continuous retrograde cooling of the kidney during its resection with irrigated cold saline solution through a catheterized ureter (10 patients) |
|
|
[53] | |
Renal perfusion | Cooling of the kidney with Ringer's solution through the renal artery with evacuation through an incision in the renal vein during its robotic laparoscopic resection (37 patients) |
|
|
[51] |
Gradual controlled increase of kidney temperature by machine perfusion (from 4°C to 20°C) after cold ischemia and before reperfusion (12 pigs) |
|
|
[16] | |
Intraoperative increase of blood pressure in the kidney (106 patients) |
|
|
[58] | |
Hydrodynamic fluid injection into the renal vein (retrograde) after ischemia and reperfusion (5 rats) |
|
|
[54] | |
Renal capsulotomy | Capsulotomy of the kidney after cold and warm ischemia (8 pigs) |
|
|
[55] |
Microcapsulotomy after ischemia and reperfusion (13 mice) |
|
|
[57] | |
Microcapsulotomy in combination with the introduction of endothelial stem cells (29 mice) |
|
|
Herrler T et al.40 | |
Ischemic preconditioning | Intraoperative splenic ischemic preconditioning before kidney implantation (18 rats) |
|
|
[59] |
Remote ischemic preconditioning of the lower limb before organs ischemia (18 rats) |
|
|
[60] | |
Using the MSC | Intraabdominal administration of MSC after ischemia and reperfusion of both kidneys (18 rats) |
|
|
[61] |
Introduction of MSC into the renal artery and renal vein after ischemia and reperfusion of the kidney (10 rats) |
|
|
[62] | |
Venous blood reperfusion | Introduction of own venous blood (1 ml) into the renal artery before kidney reperfusion (30 rabbits) |
|
|
[63] |
Retrograde venous kidney reperfusion before conventional arterial reperfusion (15 patients) |
|
|
[79] |
Therapeutic approach | Clinical research (0-3) | In vivo research (0-3) | In vitro research (0-3) | Total score (0-9) |
---|---|---|---|---|
Ischemic preconditioning | 3 | 3 | 3 | 9 |
Renal perfusion | 3 | 3 | 2 | 8 |
Tissue engineering | 2 | 2 | 3 | 7 |
Local cooling of the kidney | 2 | 2 | 1 | 5 |
Renal capsulotomy | 1 | 2 | 1 | 4 |
Venous blood reperfusion | 2 | 1 | 1 | 4 |
Therapeutic Approach | Clinical Approval | Difficulty of Test | Cost of Operation | Equipment Needed | Availability | Total Score |
---|---|---|---|---|---|---|
Tissue Engineering | 1 | 5 | 5 | 5 | 1 | 17 |
Local Cooling | 3 | 2 | 4 | 2 | 4 | 15 |
Renal Perfusion | 2 | 3 | 3 | 3 | 3 | 14 |
Ischemic Preconditioning | 2 | 3 | 3 | 2 | 4 | 14 |
Venous Blood Reperfusion | 2 | 2 | 4 | 3 | 3 | 14 |
Renal Capsulotomy | 1 | 4 | 2 | 4 | 2 | 13 |
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