Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

RNA Vaccines: Yeast as a Novel Antigen Vehicle

Anna Jéssica Duarte Silva
ORCID logo ,
Mylenna Máyra Gois Souza
,
Larissa Silva Macêdo
ORCID logo ,
Pedro Luiz França Neto
,
Ingrid Andressa de Moura
ORCID logo ,
Benigno Cristofer Flores Espinoza
,
Maria da Conceição Viana Invenção
ORCID logo ,
Samara Sousa de Pinho
,
Marco Antonio Turiah Machado da Gama
ORCID logo ,
Antonio Carlos de Freitas
* ORCID logo
Version 1 : Received: 25 April 2023 / Approved: 26 April 2023 / Online: 26 April 2023 (04:31:14 CEST)

How to cite: Silva, A. J. D.; Souza, M. M. G.; Macêdo, L. S.; França Neto, P. L.; Moura, I. A. D.; Espinoza, B. C. F.; Invenção, M. D. C. V.; Pinho, S. S. D.; Gama, M. A. T. M. D.; Freitas, A. C. D. RNA Vaccines: Yeast as a Novel Antigen Vehicle. Preprints 2023, 2023040956. https://doi.org/10.20944/preprints202304.0956.v1 Silva, A. J. D.; Souza, M. M. G.; Macêdo, L. S.; França Neto, P. L.; Moura, I. A. D.; Espinoza, B. C. F.; Invenção, M. D. C. V.; Pinho, S. S. D.; Gama, M. A. T. M. D.; Freitas, A. C. D. RNA Vaccines: Yeast as a Novel Antigen Vehicle. Preprints 2023, 2023040956. https://doi.org/10.20944/preprints202304.0956.v1

Abstract

In the last decades, technological advances related to RNA manipulation enabled and expanded its application in vaccine development. This approach comprises synthetic single-stranded mRNA molecules that direct the translation of the antigen responsible for activating the desired immune response. The success of RNA vaccines depends on the delivery vehicle employed. Among the systems, yeasts emerge as a new approach to a natural delivery platform. The presence of β-glucans and mannans in its wall is responsible for the adjuvant action of this system. Yeasts are already employed to deliver protein antigens, with success and efficacy demonstrated through pre-clinical and clinical trials. Yeast β-glucan capsules, microparticles, and nanoparticles are capable of modulating host immune responses and have a high capacity to carry RNA and small molecules, with bioavailability upon oral immunization and with targeting to receptors present in anti-gen-presenting cells (APCs). Besides, yeasts are interesting vehicles for the protection and specific delivery of therapeutic vaccines based on shRNA or dsRNA. In this review, we present an overview of the attributes of yeast or its derivatives for the delivery of RNA-based vaccines, discussing their current challenges and prospects for using this promising strategy.

Keywords

therapeutic vaccines; mRNA vaccines; antigenic delivery; whole yeast vaccine; delivery vehicle

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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