Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

CD4+CD31+ and CD4+CD44+ Lymphocytes in Peripheral Blood, CD8+CD31+ and CD8+CD103+ Lymphocytes in Bronchoalveolar Lavage Fluid, and Pulmonary Nodules in Predicting the Course of Pulmonary Sarcoidosis

Version 1 : Received: 25 April 2023 / Approved: 25 April 2023 / Online: 25 April 2023 (09:27:52 CEST)

A peer-reviewed article of this Preprint also exists.

Danila, E.; Aleksonienė, R.; Besusparis, J.; Gruslys, V.; Jurgauskienė, L.; Laurinavičienė, A.; Laurinavičius, A.; Mainelis, A.; Zablockis, R.; Zeleckienė, I.; Žurauskas, E.; Malickaitė, R. Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis. Biomedicines 2023, 11, 1437. Danila, E.; Aleksonienė, R.; Besusparis, J.; Gruslys, V.; Jurgauskienė, L.; Laurinavičienė, A.; Laurinavičius, A.; Mainelis, A.; Zablockis, R.; Zeleckienė, I.; Žurauskas, E.; Malickaitė, R. Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis. Biomedicines 2023, 11, 1437.

Abstract

The search for biological markers, which allow a relatively accurate assessment of the individual course of pulmonary sarcoidosis at the time of diagnosis remains one of the research priorities in this field of pulmonary medicine. The aim of our study was to investigate possible prognostic factors for pulmonary sarcoidosis with a special focus on cellular immune inflammation markers. 2 years follow-up of the study population after initial prospective and simultaneous analysis of lymphocyte activation markers expression in the blood, as well as bronchoalveolar lavage fluid (BALF), and lung biopsy tissue of patients with newly diagnosed pulmonary sarcoidosis, was done. We found that some blood and BAL fluid immunological markers and lung computed tomography (CT) patterns have been associated with a different course of sarcoidosis. We revealed five markers that had a significant negative association with the course of sarcoidosis (worsening pulmonary function tests and/or the chest CT changes) – blood CD4+CD31+ and CD4+CD44+ T lymphocytes, BALF CD8+CD31+ and CD8+CD103+ T lymphocytes and a number of lung nodules on chest CT at the time of the diagnosis. Cut-off values, sensitivity, specificity, and odds ratio for predictors of sarcoidosis progression were calculated. These markers may be reasonable predictors of sarcoidosis progression.

Keywords

sarcoidosis; bronchoalveolar lavage; chest computed tomography; biological markers

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.