Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Phytochemical and Pharmacological Research of the American Cranberry (Oxycoccus macrocarpus (Ait.) Pursh) Leaves Extract and its Aminoacids Preparation with Hepatoprotective Activity

Oleh Коshovyi
ORCID logo ,
Inna Vlasova
,
Valdas Jakstas
,
Gabriele Vilkickyte
ORCID logo ,
Vaidotas Žvikas
,
Roman Hrytsyk
,
Lyubov Grytsyk
,
Ain Raal
* ORCID logo
Version 1 : Received: 19 April 2023 / Approved: 20 April 2023 / Online: 20 April 2023 (05:28:46 CEST)

A peer-reviewed article of this Preprint also exists.

Koshovyi, O.; Vlasova, I.; Jakštas, V.; Vilkickytė, G.; Žvikas, V.; Hrytsyk, R.; Grytsyk, L.; Raal, A. American Cranberry (Oxycoccus macrocarpus (Ait.) Pursh) Leaves Extract and Its Amino-Acids Preparation: The Phytochemical and Pharmacological Study. Plants 2023, 12, 2010. Koshovyi, O.; Vlasova, I.; Jakštas, V.; Vilkickytė, G.; Žvikas, V.; Hrytsyk, R.; Grytsyk, L.; Raal, A. American Cranberry (Oxycoccus macrocarpus (Ait.) Pursh) Leaves Extract and Its Amino-Acids Preparation: The Phytochemical and Pharmacological Study. Plants 2023, 12, 2010.

Abstract

The liver performs a fundamental role in the regulation of diverse physiological processes. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, offer complete protection to the organ, or aid in regenerating hepatic cells. Thus, it is necessary to identify alternative plant-origin pharmaceuticals more effective and less toxic for the treatment of hepatic diseases. The aim of this research was to establish the chemical composition of the American cranberry (Oxycoccus macrocarpus) leaves extract and its aminoacids preparations as well as their hepatoprotective activity. 19 phenolic compounds (8 flavonoids (flavones and flavonols), 4 anthocyanins, 2 catechins, and 3 hydroxycinnamic acids) and main amino acids (valine, arginine, glycine, histidine, aspartic acid, and taurine) were identified and quantified in the American cranberry (O. macrocarpus) leaves extract and its 7 aminoacids preparations. The therapeutic and prophylactic consumption of the American cranberry leaves extracts led to a decrease in the intensity of the lipid peroxidation process compared to the control pathology group in the experiment of acute toxic damage to the liver by tetrachloromethane on rats. The most pronounced hepatoprotective activity was established for the American cranberry leaves extracts’ preparations with arginine and valine.

Keywords

American cranberry (Oxycoccus macrocarpus); leaves; extract; modification; amino acid; hepatoprotective activity.

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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