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Iron Complexes With Antarctic Krill-Derived Peptides Show Su-Perior Effectiveness to Their Original Protein-Iron Complexes in Mice With Iron Deficiency Anemia
Hu, S.; Lin, S.; Feng, Q.; He, X.; Xu, H.; Chen, L.; Sun, N. Iron Complexes with Antarctic Krill–Derived Peptides Show Superior Effectiveness to Their Original Protein–Iron Complexes in Mice with Iron Deficiency Anemia. Nutrients2023, 15, 2510.
Hu, S.; Lin, S.; Feng, Q.; He, X.; Xu, H.; Chen, L.; Sun, N. Iron Complexes with Antarctic Krill–Derived Peptides Show Superior Effectiveness to Their Original Protein–Iron Complexes in Mice with Iron Deficiency Anemia. Nutrients 2023, 15, 2510.
Hu, S.; Lin, S.; Feng, Q.; He, X.; Xu, H.; Chen, L.; Sun, N. Iron Complexes with Antarctic Krill–Derived Peptides Show Superior Effectiveness to Their Original Protein–Iron Complexes in Mice with Iron Deficiency Anemia. Nutrients2023, 15, 2510.
Hu, S.; Lin, S.; Feng, Q.; He, X.; Xu, H.; Chen, L.; Sun, N. Iron Complexes with Antarctic Krill–Derived Peptides Show Superior Effectiveness to Their Original Protein–Iron Complexes in Mice with Iron Deficiency Anemia. Nutrients 2023, 15, 2510.
Abstract
Antarctic krill protein-iron complex and peptide-iron complex were obtained to investigate their iron bioavailability, expression of iron-regulated genes, and in vivo antioxidant capacity. Results indicated that Antarctic krill peptide-iron complex increased significantly the hemoglobin (Hb), serum iron (SI) and iron content in the liver and spleen in iron-deficiency anemia (IDA) mice (P < 0.05) compared with those of Antarctic krill protein-iron complex. Despite the gene expressions of divalent metal transporter 1(DMT1), transferrin (Tf) and transferrin receptor (TfR) could be better regulated by both Antarctic krill peptide-iron complex and protein-iron complex, the relative iron bioavailability of the Antarctic krill peptide-iron complex group (152.53±21.05%) was significantly higher than that of the protein-iron complex group (112.75±9.60%) (P<0.05). Moreover, Antarctic krill peptide-iron complex could enhance the antioxidant enzyme activities of superoxidase dismutase (SOD) and glutathione peroxidase (GSH-Px), reduce the malondialdehyde (MDA) level in IDA mice compared with the protein-iron complex, reducing the cell damage caused by IDA. Therefore, these results demonstrated that Antarctic krill peptide-iron complex could be used as a highly efficient and multifunctional iron supplement.
Keywords
IDA mice; Antarctic krill peptide-iron; iron-regulated genes; iron bioavailability; in vivo antioxidant capacity
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
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