Version 1
: Received: 13 April 2023 / Approved: 13 April 2023 / Online: 13 April 2023 (09:41:04 CEST)
How to cite:
Silva, M.; Santos, F.; Lagares, L.; Macedo, R.; Takanami, L.; Almeida, L.; Bomfim, E.; Santos, C. Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials. Preprints2023, 2023040318. https://doi.org/10.20944/preprints202304.0318.v1
Silva, M.; Santos, F.; Lagares, L.; Macedo, R.; Takanami, L.; Almeida, L.; Bomfim, E.; Santos, C. Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials. Preprints 2023, 2023040318. https://doi.org/10.20944/preprints202304.0318.v1
Silva, M.; Santos, F.; Lagares, L.; Macedo, R.; Takanami, L.; Almeida, L.; Bomfim, E.; Santos, C. Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials. Preprints2023, 2023040318. https://doi.org/10.20944/preprints202304.0318.v1
APA Style
Silva, M., Santos, F., Lagares, L., Macedo, R., Takanami, L., Almeida, L., Bomfim, E., & Santos, C. (2023). Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials. Preprints. https://doi.org/10.20944/preprints202304.0318.v1
Chicago/Turabian Style
Silva, M., Eric Bomfim and Clarcson Santos. 2023 "Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials" Preprints. https://doi.org/10.20944/preprints202304.0318.v1
Abstract
Aim: To investigate how much aerobic and resisted physical exercise affects the behavior of AST and ALT proteins in the NAFLD spectrum. Background: Non-alcoholic fatty liver disease (NAFLD) is a pathology resulting from the excessive accumulation of triglycerides in the liver. The pathophysiology of the disease comes from several mechanisms, among them, metabolic, environmental, and genetic. The measurement of liver enzymes, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) are essential to perform a differential diagnosis of NAFLD with other pathologies that affect the liver. The non-pharmacological treatment of NAFLD is based on aerobic and resisted physical exercise, and one of its aims is to reduce the inflammatory markers AST and ALT. Materials and Methods: Systematic review carried out in PubMed, Scopus, Embase, and Cochrane databases. Clinical trials that evaluated the effect of physical exercise on NAFLD on AST and ALT enzymes were included. Results: A total of 24 clinical trials met the inclusion criteria, with a sample size of 1141 participants, aged 20-82 years. The study protocol varied between aerobic exercise and resistance exercise with a weekly frequency between 2-6 times a week, a duration of 20-90 minutes for aerobics, and an intensity between 50-80% of peak VO2 and/or maximum HR for the resisted. Of the 24 studies included, only five showed improvements in both enzymes in the intervention group. Conclusion: Physical exercise cannot make significant changes in the behavior of AST and ALT liver parameters.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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