Kabir, R.; Malik, I.; Chen, R.; Nahar, J.; Chen, X.; Hoq, M.; Kabir, A. D-dimer Trends Predicts COVID-19 Patient’s Prognosis: A Retrospective Chart Review Study. Preprints2023, 2023040298. https://doi.org/10.20944/preprints202304.0298.v1
APA Style
Kabir, R., Malik, I., Chen, R., Nahar, J., Chen, X., Hoq, M., & Kabir, A. (2023). D-dimer Trends Predicts COVID-19 Patient’s Prognosis: A Retrospective Chart Review Study. Preprints. https://doi.org/10.20944/preprints202304.0298.v1
Chicago/Turabian Style
Kabir, R., Mahfouz Hoq and Azad Kabir. 2023 "D-dimer Trends Predicts COVID-19 Patient’s Prognosis: A Retrospective Chart Review Study" Preprints. https://doi.org/10.20944/preprints202304.0298.v1
Abstract
Abstract: This is a retrospective study of patients admitted to Jackson Hospital, Montgomery, Alabama with a diagnosis of COVID-19 from January 1, 2021, to February 15, 2022. The independent variable used in the models were patient sex, age, race, BMI category, daily D-dimer categories, categories of anticoagulation doses (Enoxaparin 40 mg VS. Enoxaparin 80 mg VS Enoxaparin 1mg/kg or equivalent), bleeding episodes, and vaccination status. The three different categories of anticoagulation doses were considered for the purpose of the study. Results: The study reviewed a total of one hundred (100) hospitalized patients. Intermediate-dose anticoagulation was found to be the optimal dose as only fourteen percent (14%) patients died compared to a thirty-six percent (36%) and fifty percent (57%) death rate among those treated with low-dose and high-dose anticoagulation, respectively. The multivariate linear regression model predicting patient oxygen requirements revealed D-Dimer and bleeding status to be statistically significant predictors with a p value of <0.01. For the patients who had a D-dimer value ≥ 2 µg/mL, the oxygenation requirement was predicted to be 31 L higher than those with a D-dimer <2 µg/mL (99% CI; p<0.01). When mean D-dimer and corresponding oxygen requirements were calculated per hospitalization days category, the D-dimer levels and oxygen requirements were noted to follow the same trends indicating both values tended to increase and decrease simultaneously. Conclusion: The study concludes daily D-dimer trends can predict COVID-19 patient survival or daily oxygen requirements indicating D-dimer can be the miracle molecule for COVID-19 prognosis.
Copyright:
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