Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Current Applications of Liposomes for the Delivery of Bioactives: A Review on the Encapsulation of Vitamins

Authors contributed equally to this work.
Version 1 : Received: 11 April 2023 / Approved: 12 April 2023 / Online: 12 April 2023 (02:54:13 CEST)

A peer-reviewed article of this Preprint also exists.

Chaves, M.A.; Ferreira, L.S.; Baldino, L.; Pinho, S.C.; Reverchon, E. Current Applications of Liposomes for the Delivery of Vitamins: A Systematic Review. Nanomaterials 2023, 13, 1557. Chaves, M.A.; Ferreira, L.S.; Baldino, L.; Pinho, S.C.; Reverchon, E. Current Applications of Liposomes for the Delivery of Vitamins: A Systematic Review. Nanomaterials 2023, 13, 1557.

Abstract

Liposomes have been used for several decades for the encapsulation of drugs and bioactives in cosmetics and cosmeceuticals. On the other hand, the use of these phospholipid vesicles in food applications is more recent and has been increasing significantly in the last ten years. Although in different stages of technological maturity - in the case of cosmetics, many products are on the market - processes to obtain liposomes suitable for the encapsulation and delivery of bioactives are highly expensive, especially aiming at scaling-up. Among the bioactives proposed for cosmetics and food applications, vitamins are the most frequently used. Despite the differences between the administration routes (oral for food and mainly dermal for cosmetics), some challenges are very similar (e.g., stability, bioactive load, average size, increase of drug bioaccessibility and bioavailability). In the present work, a systematic review of the technological advancements in the nanoencapsulation of vitamins using liposomes and related processes was performed; challenges and future perspectives were also discussed in order to underline the advantages of these drug loaded biocompatible nanocarriers for cosmetics and food applications.

Keywords

vitamins; nanoencapsulation; nanodispersions; phospholipid vesicles; liposomes; cosmetics; food application

Subject

Chemistry and Materials Science, Nanotechnology

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