Version 1
: Received: 11 April 2023 / Approved: 11 April 2023 / Online: 11 April 2023 (08:03:02 CEST)
How to cite:
Ji, T.; Fang, B.; Zhang, M.; Liu, Y. Supplement of Succinate Reduces Lipid Deposition and Improves Metabolic Function in Obese Mice. Preprints2023, 2023040208. https://doi.org/10.20944/preprints202304.0208.v1
Ji, T.; Fang, B.; Zhang, M.; Liu, Y. Supplement of Succinate Reduces Lipid Deposition and Improves Metabolic Function in Obese Mice. Preprints 2023, 2023040208. https://doi.org/10.20944/preprints202304.0208.v1
Ji, T.; Fang, B.; Zhang, M.; Liu, Y. Supplement of Succinate Reduces Lipid Deposition and Improves Metabolic Function in Obese Mice. Preprints2023, 2023040208. https://doi.org/10.20944/preprints202304.0208.v1
APA Style
Ji, T., Fang, B., Zhang, M., & Liu, Y. (2023). Supplement of Succinate Reduces Lipid Deposition and Improves Metabolic Function in Obese Mice. Preprints. https://doi.org/10.20944/preprints202304.0208.v1
Chicago/Turabian Style
Ji, T., Ming Zhang and Yaqiong Liu. 2023 "Supplement of Succinate Reduces Lipid Deposition and Improves Metabolic Function in Obese Mice" Preprints. https://doi.org/10.20944/preprints202304.0208.v1
Abstract
The number of obese people worldwide is rising dramatically, with 51% of the global population expected to be obese or overweight by 2035. And it is usually involved in a variety of chronic diseases, including diabetes, hypertension, cardiovascular and cerebrovascular diseases. In the process of obesity, adipose tissue expands indefinitely, which induces metabolic dysfunction. Here, we confirm the role of succinate in the intervention of obesity. Through adding succinate to drinking water, high-fat diet induced obese mice were associated with the lower fat mass, and improved glucose tolerance and energy expenditure. These metabolic changes are accompanied by increased expression of lipolysis genes and decreased lipogenesis genes, especially in subcutaneous adipose tissue. In summary, supplement of succinate improves lipid deposition and metabolic health in obese mice.
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
