Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Rottlerin-Liposome Inhibits Endocytosis of Feline Infectious Peritonitis Virus Infection Through PKCδ Dependent Manner

Jong-Chul Choi
ORCID logo ,
Sung-Won Jung
,
In-Yeong Choi
,
Yeong-Lim Kang
,
Dong-Hun Lee
,
Sang-Won Lee
,
Seung-Yong Park
,
Chang-Seon Song
ORCID logo ,
In-Soo Choi
,
Joong-Bok Lee
ORCID logo ,
Changin Oh
* ORCID logo
Version 1 : Received: 6 April 2023 / Approved: 7 April 2023 / Online: 7 April 2023 (03:40:34 CEST)

A peer-reviewed article of this Preprint also exists.

Choi, J.-C.; Jung, S.-W.; Choi, I.-Y.; Kang, Y.-L.; Lee, D.-H.; Lee, S.-W.; Park, S.-Y.; Song, C.-S.; Choi, I.-S.; Lee, J.-B.; Oh, C. Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection. Vet. Sci. 2023, 10, 380. Choi, J.-C.; Jung, S.-W.; Choi, I.-Y.; Kang, Y.-L.; Lee, D.-H.; Lee, S.-W.; Park, S.-Y.; Song, C.-S.; Choi, I.-S.; Lee, J.-B.; Oh, C. Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection. Vet. Sci. 2023, 10, 380.

Abstract

Rottlerin(R) is a natural extract from Mallotus philippensis with antiviral properties. Feline Infectious Peritonitis (FIP) is a fatal disease characterized by systemic granulomatous inflammation and high mortality, with no established prevention or cure. We investigated antiviral effect of liposome loaded R, Rottlerin-liposome(RL) against Feline infectious peritonitis virus (FIPV), the causative agent. We demonstrated that R and RL inhibited FIPV replication in dose dependently with a PKCδ related manner, not only in the early endocytosis step but also in the late step of replication. RL resolved the low solubility issue of rottlerin and improved its inhibition efficacy at the cellular level. Based on these findings, we suggest that RL has a value for further research as a potential antiviral agent against FIPV.

Keywords

Feline Infectious Peritonitis; Rottlerin; Drug Delivery System; Liposome; Antivirals

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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