Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine

Giovanni Corsetti
* ORCID logo ,
Claudia Romano
,
Tiziano Scarabelli
,
Carol Chen-Scarabelli
,
Evasio Pasini
,
And Francesco S Dioguardi
* ORCID logo
Version 1 : Received: 5 April 2023 / Approved: 5 April 2023 / Online: 5 April 2023 (15:45:18 CEST)

How to cite: Corsetti, G.; Romano, C.; Scarabelli, T.; Chen-Scarabelli, C.; Pasini, E.; Dioguardi, A.F.S. Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine. Preprints 2023, 2023040068. https://doi.org/10.20944/preprints202304.0068.v1 Corsetti, G.; Romano, C.; Scarabelli, T.; Chen-Scarabelli, C.; Pasini, E.; Dioguardi, A.F.S. Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine. Preprints 2023, 2023040068. https://doi.org/10.20944/preprints202304.0068.v1

Abstract

Abstract: Cancer cells are originated by normal cells and with those share the need to be fed. Metabolic reprogramming in cancer cells is not yet fully understood although there is a vast literature suggesting that huge amounts of both energy and substrates are require for synthesis of components of new neoplastic cells so that any macronutrient may be efficiently utilized. Recently, in vitro data show that EAA supplementation promoted colon cancer cells apoptosis by enhanced autophagy. Therefore, in this study we tested in vivo the effects of matched macronutrients standard laboratory diet (control) versus EAA rich modified diet (EAArmd) in mice injected with colon cancer cells. Results of the first set of 12 animals, 6 controls and 6 EAArmd-fed, showed that controls mice develop cancer volume cancers 5 times larger and heavier than EAArmd-fed. If confirmed, these results would open new scenarios for the cancer integrate therapies.

Keywords

cancer; amino acids; colon; nitrogen; diet; mice

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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