Version 1
: Received: 5 April 2023 / Approved: 5 April 2023 / Online: 5 April 2023 (15:45:18 CEST)
How to cite:
Corsetti, G.; Romano, C.; Scarabelli, T.; Chen-Scarabelli, C.; Pasini, E.; Dioguardi, A. F. S. Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine. Preprints2023, 2023040068. https://doi.org/10.20944/preprints202304.0068.v1
Corsetti, G.; Romano, C.; Scarabelli, T.; Chen-Scarabelli, C.; Pasini, E.; Dioguardi, A. F. S. Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine. Preprints 2023, 2023040068. https://doi.org/10.20944/preprints202304.0068.v1
Corsetti, G.; Romano, C.; Scarabelli, T.; Chen-Scarabelli, C.; Pasini, E.; Dioguardi, A. F. S. Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine. Preprints2023, 2023040068. https://doi.org/10.20944/preprints202304.0068.v1
APA Style
Corsetti, G., Romano, C., Scarabelli, T., Chen-Scarabelli, C., Pasini, E., & Dioguardi, A. F. S. (2023). Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine. Preprints. https://doi.org/10.20944/preprints202304.0068.v1
Chicago/Turabian Style
Corsetti, G., Evasio Pasini and And Francesco S Dioguardi. 2023 "Preliminary Data : Feeding and Colon Cancer Growth. Modified Nitrogen Intake Leads to Blunted Cancer Growth Independently by Serine" Preprints. https://doi.org/10.20944/preprints202304.0068.v1
Abstract
Abstract: Cancer cells are originated by normal cells and with those share the need to be fed. Metabolic reprogramming in cancer cells is not yet fully understood although there is a vast literature suggesting that huge amounts of both energy and substrates are require for synthesis of components of new neoplastic cells so that any macronutrient may be efficiently utilized. Recently, in vitro data show that EAA supplementation promoted colon cancer cells apoptosis by enhanced autophagy. Therefore, in this study we tested in vivo the effects of matched macronutrients standard laboratory diet (control) versus EAA rich modified diet (EAArmd) in mice injected with colon cancer cells. Results of the first set of 12 animals, 6 controls and 6 EAArmd-fed, showed that controls mice develop cancer volume cancers 5 times larger and heavier than EAArmd-fed. If confirmed, these results would open new scenarios for the cancer integrate therapies.
Keywords
cancer; amino acids; colon; nitrogen; diet; mice
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.